Evidence map›Paper›PMID 26453570›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2016

Serial scanning with technetium pyrophosphate (

Adam Castaño, Albert DeLuca, Richard Weinberg, Ted Pozniakoff, William S Blaner, Altaf Pirmohamed, Brian Bettencourt, Jared Gollob, Verena Karsten, John A Vest and 3 more

Abstract read
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Multimodality Imaging in Cardiac Amyloidosis.Journal of clinical medicine · 2025
    Review
  6. Article
  7. Imaging of cardiac amyloidosis using dynamicAnnals of nuclear medicine · 2025
    Article
  8. Review
  9. Review
  10. Clinical significance of quantitative assessment of right ventricular amyloid burden with [European journal of nuclear medicine and molecular imaging · 2025
    Article
  11. 2025 Update Consensus ofActa Cardiologica Sinica · 2025
    Article
  12. Review
  13. Review
  14. Evolution of cardiac amyloidosis imaging with bone-avid tracers: From qualification to quantification.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2024
    Article
  15. QuantitativeJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2024
    Article
  16. Article
  17. Cardiac [European journal of nuclear medicine and molecular imaging · 2024
    Article
  18. Article
  19. Review
  20. Transthyretin amyloid cardiomyopathy disease burden quantified usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Adam CastañoNuclear Cardiology Laboratory, Columbia College of Physicians & Surgeons, 622 W 168th St. P.H. 10-203, New York, NY, 10032, USA. ac3220@cumc.columbia.edu.
Albert DeLucaNuclear Cardiology Laboratory, Columbia College of Physicians & Surgeons, 622 W 168th St. P.H. 10-203, New York, NY, 10032, USA.
Richard WeinbergNuclear Cardiology Laboratory, Columbia College of Physicians & Surgeons, 622 W 168th St. P.H. 10-203, New York, NY, 10032, USA.
Ted PozniakoffNuclear Cardiology Laboratory, Columbia College of Physicians & Surgeons, 622 W 168th St. P.H. 10-203, New York, NY, 10032, USA.
William S BlanerDepartment of Medicine, Institute of Human Nutrition, Columbia College of Physicians & Surgeons, New York, NY, USA.
Altaf PirmohamedNuclear Cardiology Laboratory, Columbia College of Physicians & Surgeons, 622 W 168th St. P.H. 10-203, New York, NY, 10032, USA.
Brian BettencourtAlnylam Pharmaceuticals, Cambridge, MA, USA.
Jared GollobAlnylam Pharmaceuticals, Cambridge, MA, USA.
Verena KarstenAlnylam Pharmaceuticals, Cambridge, MA, USA.
John A VestAlnylam Pharmaceuticals, Cambridge, MA, USA.
Codruta ChiuzanMailman School of Public Health, Columbia College of Physicians & Surgeons, New York, NY, USA.
Mathew S MaurerDivision of Cardiology, Center for Advanced Cardiac Care, Columbia College of Physicians & Surgeons, New York, NY, USA.
Sabahat BokhariNuclear Cardiology Laboratory, Columbia College of Physicians & Surgeons, 622 W 168th St. P.H. 10-203, New York, NY, 10032, USA.
Columbia University · USAlnylam Pharmaceuticals (United States) · US

Funding

Postprandial Vitamin AR01DK068437 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S · 2004 to 2023
$7.0M
Midcareer Mentoring Award for Patient Oriented Research in Geriatric CardiologyK24AG036778 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAURER, MATHEW S · 2010 to 2020
$1.6M
Vitamin A Homeostasis: Retinyl Ester StoresR01DK101251 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S, HARRISON, EARL HOWARD · 2016 to 2018
$1.4M
NIA NIH HHS K24 AG036778NIDDK NIH HHS R01 DK068437NIDDK NIH HHS R01 DK101251
6 · The paper itself

Abstract

backgroundDevelopment of noninvasive imaging modalities to quantify amyloid burden over time is an unmet clinical need. Technetium pyrophosphate ( METHODS AND

resultsTwenty subjects with ATTR-CA (10 wild type, 10 mutant) underwent serial

conclusionsSerial

Indexed as

Subtraction TechniqueTechnetium Tc 99m PyrophosphateAgedAmyloidosisCardiomyopathiesFemaleHumansImage EnhancementLongitudinal StudiesMaleRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificitySingle-Blind MethodRadiopharmaceuticalsTechnetium Tc 99m Pyrophosphate99mTc-PYP technetium pyrophosphate imagingAL amyloidATTR-CA transthyretin cardiac amyloidosis

Identifiers

PMID26453570
PMCPMC4826633
OpenAlexW1843945506

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.