ArticleNeuroradiology2016
Anatomical specificity of vascular endothelial growth factor expression in glioblastomas: a voxel-based mapping analysis.
Article in Neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Data-driven probabilistic mapping of the spatial and molecular landscape of glioma.Brain communications · 2026Article
- Clinical Significance of Early Venous Filling Detected via Preoperative Angiography in Glioblastoma.Cancers · 2023Article
- New insights into glioma frequency maps: From genetic and transcriptomic correlate to survival prediction.International journal of cancer · 2023Article
- The involvement of brain regions associated with lower KPS and shorter survival time predicts a poor prognosis in glioma.Frontiers in neurology · 2023Article
- Radiogenomic analysis of vascular endothelial growth factor in patients with diffuse gliomas.Cancer imaging : the official publication of the International Cancer Imaging Society · 2019Article
- Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression.Oncotarget · 2016Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe expression of vascular endothelial growth factor (VEGF) is a common genetic alteration in malignant gliomas and contributes to the angiogenesis of tumors. This study aimed to investigate the anatomical specificity of VEGF expression levels in glioblastomas using voxel-based neuroimaging analysis.
methodsClinical information, MR scans, and immunohistochemistry stains of 209 patients with glioblastomas were reviewed. All tumor lesions were segmented manually and subsequently registered to standard brain space. Voxel-based regression analysis was performed to correlate the brain regions of tumor involvement with the level of VEGF expression. Brain regions identified as significantly associated with high or low VEGF expression were preserved following permutation correction.
resultsHigh VEGF expression was detected in 123 (58.9 %) of the 209 patients. Voxel-based statistical analysis demonstrated that high VEGF expression was more likely in tumors located in the left frontal lobe and the right caudate and low VEGF expression was more likely in tumors that occurred in the posterior region of the right lateral ventricle.
conclusionVoxel-based neuroimaging analysis revealed the anatomic specificity of VEGF expression in glioblastoma, which may further our understanding of genetic heterogeneity during tumor origination. This finding provides primary theoretical support for potential future application of customized antiangiogenic therapy.
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