ArticleJournal of molecular neuroscience : MN2016
Expression and Localization of Connexins in the Outer Retina of the Mouse.
Article in Journal of molecular neuroscience : MN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Targeting Connexins Biology as Therapeutic Strategies Against Retinal Diseases.Advances in experimental medicine and biology · 2025Review
- When microscopy and electrophysiology meet connectomics-Steve Massey's contribution to unraveling the structure and function of the rod/cone gap junction.Frontiers in ophthalmology · 2023Review
- Analysis of rod/cone gap junctions from the reconstruction of mouse photoreceptor terminals.eLife · 2022Article
- Interphotoreceptor coupling: an evolutionary perspective.Pflugers Archiv : European journal of physiology · 2021Review
- Molecular and functional architecture of the mouse photoreceptor network.Science advances · 2020Article
- Rod and Cone Coupling Modulates Photopic ERG Responses in the Mouse Retina.Frontiers in cellular neuroscience · 2020Article
- Connexin-36 distribution and layer-specific topography in the cat retina.Brain structure & function · 2019Article
- Localization of Retinal CaFrontiers in molecular neuroscience · 2019Article
- Rod and cone interactions in the retina.F1000Research · 2018Review
- Establishing Wiring Specificity in Visual System Circuits: From the Retina to the Brain.Annual review of neuroscience · 2017Review
- Connexin36 Expression in the Mammalian Retina: A Multiple-Species Comparison.Frontiers in cellular neuroscience · 2017Article
- Connexin30.2: In Vitro Interaction with Connexin36 in HeLa Cells and Expression in AII Amacrine Cells and Intrinsically Photosensitive Ganglion Cells in the Mouse Retina.Frontiers in molecular neuroscience · 2016Article
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Authors and funding
8 authors.
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Abstract
The identification of the proteins that make up the gap junction channels between rods and cones is of crucial importance to understand the functional role of photoreceptor coupling within the retinal network. In vertebrates, connexin proteins constitute the structural components of gap junction channels. Connexin36 is known to be expressed in cones whereas extensive investigations have failed to identify the corresponding connexin expressed in rods. Using immunoelectron microscopy, we demonstrate that connexin36 (Cx36) is present in gap junctions of cone but not rod photoreceptors in the mouse retina. To identify the rod connexin, we used nested reverse transcriptase polymerase chain reaction and tested retina and photoreceptor samples for messenger RNA (mRNA) expression of all known connexin genes. In addition to connexin36, we detected transcripts for connexin32, connexin43, connexin45, connexin50, and connexin57 in photoreceptor samples. Immunohistochemistry showed that connexin43, connexin45, connexin50, and connexin57 proteins are expressed in the outer plexiform layer. However, none of these connexins was detected at gap junctions between rods and cones as a counterpart of connexin36. Therefore, the sought-after rod protein must be either an unknown connexin sequence, a connexin36 splice product not detected by our antibodies, or a protein from a further gap junction protein family.
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