Evidence map›Paper›PMID 26453528›Full record

Observational studyJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2015

Anemia and its association with clinical outcome in heart failure patients undergoing cardiac resynchronization therapy.

Ramkumar V Venkateswaran, Carolyn Freeman, Neal Chatterjee, Jagdesh Kandala, Mary Orencole, Eszter M Vegh, Kimberly A Parks, Peter J Cowburn, G William Dec, Jagmeet P Singh and 1 more

Abstract readObservational Study
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In one paragraph

Observational study in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Ramkumar V VenkateswaranHarvard Medical School, Boston, MA, USA.
Carolyn FreemanMassachusetts General Hospital, Cardiology Division, Boston, MA, USA.
Neal ChatterjeeMassachusetts General Hospital, Cardiology Division, Boston, MA, USA.
Jagdesh KandalaMassachusetts General Hospital, Cardiology Division, Boston, MA, USA.
Mary OrencoleMassachusetts General Hospital, Cardiology Division, Boston, MA, USA.
Eszter M VeghMassachusetts General Hospital, Cardiology Division, Boston, MA, USA.
Kimberly A ParksMassachusetts General Hospital, Cardiology Division, Boston, MA, USA.
Peter J CowburnUniversity Hospital Southampton NHS Foundation Trust, Southampton, UK.
G William DecHarvard Medical School, Boston, MA, USA.
Jagmeet P SinghMassachusetts General Hospital, Cardiology Division, Boston, MA, USA.
Rasmus BorgquistMassachusetts General Hospital, Cardiology Division, Boston, MA, USA. rasmus.borgquist@med.lu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAlthough a substantial proportion of patients with heart failure (HF) have anemia, there is a paucity of data evaluating the impact of anemia on clinical outcome in CRT patients. Our goal was to examine the ability of baseline hemoglobin (Hb) level and change in Hb level over time to predict clinical 2-year outcome and echocardiographic response to CRT.

methodsThree hundred consecutive CRT patients (median 72 years [interquartile range (IQR) 16 years], 19% female) with baseline and follow-up hematological profiles available were examined. Baseline anemia was defined as Hb <12 g/dL in women and <13 g/dL in men, and patients were grouped into equal quartiles based on change in Hb. Two-year clinical outcome was determined using a composite endpoint that included HF hospitalization, left ventricular assist device (LVAD) placement, heart transplantation, and all-cause mortality. Echocardiographic reverse remodeling was examined at 6-month follow-up.

resultsOne hundred fifty-one anemic patients were compared to 149 non-anemic patients. Changes in left ventricular dimensions and ejection fraction were similar for both groups. Univariate predictors of 2-year clinical outcome included baseline creatinine level, diuretic usage, and anemia; in multivariable regression, baseline anemia was an independent predictor for outcome (hazard ratio [HR] 1.79, 95% confidence interval [CI] [1.22-2.63], p = 0.003). The quartile with the most negative change in Hb concentration over time (≤-1.00 g/dL) had poorer event-free 2-year survival (HR 1.84, CI [1.13-3.00], p = 0.014).

conclusionsBaseline anemia and early postimplantation decline in Hb levels are associated with a worse 2-year prognosis in CRT patients, even though the magnitude of left ventricular reverse remodeling is similar compared to non-anemic patients.

Indexed as

AgedAnemiaBiomarkersBostonCardiac Resynchronization TherapyComorbidityFemaleHeart FailureHemoglobinsHumansIncidenceMalePrognosisRetrospective StudiesRisk FactorsSurvival RateBiomarkersHemoglobinsAnemiaCardiac resynchronization therapyHeart failurePrognostic factorsRisk stratification

Identifiers

PMID26453528

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.