Evidence map›Paper›PMID 26453502›Full record

ReviewBone2015

Inflammation induced loss of skeletal muscle.

Priya Londhe, Denis C Guttridge

Registry-linked trialAbstract readReview
In one paragraph

Review in Bone, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06620484 (Musculoskeletal Ultrasound with Elastography in the Evaluation of Muscle State in Rheumatoid Arthritis Patients), which is not on this map. Cited by 175 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed, 5 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06620484 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Musculoskeletal Ultrasound with Elastography in the Evaluation of Muscle State in Rheumatoid Arthritis Patients

TypeobservationalSponsorAssiut UniversityRan2024 to 2025Enrolled72ConditionsRheumatoid Arthritis, Musculoskeletal UltrasoundArmsMusculoskeletal Ultrasound with elastography
3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 5 syntheses or guidelines pooled it, 265 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Variability in resistance training trajectories of breast cancer patients undergoing therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Molecular medicine reports · 2026
    Article
  17. Review
  18. Parthenolide Attenuates Skeletal Muscle Atrophy Through Regulation of Protein Homeostasis and Inhibition of Inflammation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  19. Review
  20. Review

115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Priya LondheDepartment of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Arthur G. James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
Denis C GuttridgeDepartment of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Arthur G. James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA. Electronic address: denis.guttridge@osumc.edu.
Cancer Genetics (United States) · USThe Ohio State University · US

Funding

NF-kB/IKK signaling in myogenesis and diseaseR01AR052787 · NIAMS · OHIO STATE UNIVERSITY · PI GUTTRIDGE, DENIS C · 2007 to 2016
$3.1M
NIAMS NIH HHS R01 AR052787
6 · The paper itself

Abstract

Inflammation is an important contributor to the pathology of diseases implicated in skeletal muscle dysfunction. A number of diseases and disorders including inflammatory myopathies and Chronic Obstructive Pulmonary Disorder (COPD) are characterized by chronic inflammation or elevation of the inflammatory mediators. While these disease states exhibit different pathologies, all have in common the loss of skeletal muscle mass and a deregulated skeletal muscle physiology. Pro-inflammatory cytokines are key contributors to chronic inflammation found in many of these diseases. This section of the review focuses on some of the known inflammatory disorders like COPD, Rheumatoid Arthritis (RA) and inflammatory myopathies that display skeletal muscle atrophy and also provides the reader an overview of the mediators of inflammation, their signaling pathways, and mechanisms of action. This article is part of a Special Issue entitled "Muscle Bone Interactions".

Indexed as

AnimalsCytokinesHumansInflammationMuscle, SkeletalMuscular AtrophyCytokinesAtrophyCytokinesDifferentiationInflammationMuscleSkeletal

Identifiers

PMID26453502
PMCPMC4600538
OpenAlexW2161607478

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.