Evidence map›Paper›PMID 26453491›Full record

ReviewTrends in genetics : TIG2015

miRNA Nomenclature: A View Incorporating Genetic Origins, Biosynthetic Pathways, and Sequence Variants.

T Desvignes, P Batzel, E Berezikov, K Eilbeck, J T Eppig, M S McAndrews, A Singer, J H Postlethwait

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in genetics : TIG, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Design, Synthesis and Biophysical Characterisation of CPP-PNA Conjugates for Targeting Oncogenic microRNA-221.Journal of peptide science : an official publication of the European Peptide Society · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

T DesvignesInstitute of Neuroscience, University of Oregon, Eugene, OR 97403, USA.
P BatzelInstitute of Neuroscience, University of Oregon, Eugene, OR 97403, USA.
E BerezikovEuropean Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, The Netherlands.
K EilbeckUtah Science, Technology, and Research Center for Genetic Discovery, University of Utah, Salt Lake City, UT 84112, USA; Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84112, USA.
J T EppigMouse Genome Informatics, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
M S McAndrewsMouse Genome Informatics, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
A SingerZFIN, 5291 University of Oregon, Eugene, OR 97403-5291, USA.
J H PostlethwaitInstitute of Neuroscience, University of Oregon, Eugene, OR 97403, USA. Electronic address: jpostle@uoneuro.uoregon.edu.

Funding

SOFTWARE AND DATABASE SYSTEM DEVELOPMENTP41HG000330 · NHGRI · JACKSON LABORATORY · PI EPPIG, JANAN T. · 1995 to 2010
$72.1M
Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
Mouse Genome DatabaseU41HG000330 · NHGRI · JACKSON LABORATORY · PI BLAKE, JUDITH A, BULT, CAROL J · 2011 to 2020
$45.5M
Zebrafish FacilityP01HD022486 · NICHD · UNIVERSITY OF OREGON · PI PARTHASARATHY, RAGHUVEER · 1987 to 2017
$28.8M
Resources for Teleost Gene Duplicates and Human DiseaseR01OD011116 · OD · UNIVERSITY OF OREGON · PI POSTLETHWAIT, JOHN H. · 2012 to 2020
$5.4M
RESOURCES FOR TELEOST GENE DUPLICATES AND HUMAN DISEASER01RR020833 · NCRR · UNIVERSITY OF OREGON · PI POSTLETHWAIT, JOHN H. · 2005 to 2011
$3.6M
InterMOD: integrated data and tools to support model organism researchR01HG004834 · NHGRI · UNIVERSITY OF CAMBRIDGE · PI CHERRY, J. MICHAEL, MICKLEM, GOS · 2009 to 2013
$2.8M
An Ontology of Qualities for the Annotation of Biomedical DataR01HG004838 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI LEWIS, SUZANNA E · 2009 to 2012
$1.9M
Idenfication of miRNAs involved midfacial development and cleftingU01DE020076 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI ARTINGER, KRISTIN, CLOUTHIER, DAVID E. · 2009 to 2013
$1.9M
Advancing the Scientific Potential of Transcriptomics in Aquatic ModelsR24OD011199 · OD · UNIVERSITY OF OREGON · PI CRESKO, WILLIAM A, POSTLETHWAIT, JOHN H. · 2012 to 2014
$1.8M
Softward to facilitate adoption of the Sequence Ontology for genome managementR01HG004341 · NHGRI · UNIVERSITY OF UTAH · PI EILBECK, KAREN LOUISE · 2007 to 2013
$1.6M
NCI NIH HHS P30 CA034196NCRR NIH HHS R01 RR020833NHGRI NIH HHS 5P41HG000330NHGRI NIH HHS HG004834NHGRI NIH HHS HG004838NHGRI NIH HHS P41 HG000330NHGRI NIH HHS R01 HG004341NHGRI NIH HHS R01HG004341NHGRI NIH HHS R01 HG004834NHGRI NIH HHS R01 HG004838NHGRI NIH HHS U41 HG000330NICHD NIH HHS P01 HD022486NIDCR NIH HHS U01 DE020076NIDCR NIH HHS U01DE020076NIH HHS R01 OD011116NIH HHS R24 OD011199PHS HHS 5R240D011199
6 · The paper itself

Abstract

High-throughput sequencing of miRNAs has revealed the diversity and variability of mature and functional short noncoding RNAs, including their genomic origins, biogenesis pathways, sequence variability, and newly identified products such as miRNA-offset RNAs (moRs). Here we review known cases of alternative mature miRNA-like RNA fragments and propose a revised definition of miRNAs to encompass this diversity. We then review nomenclature guidelines for miRNAs and propose to extend nomenclature conventions to align with those for protein-coding genes established by international consortia. Finally, we suggest a system to encompass the full complexity of sequence variations (i.e., isomiRs) in the analysis of small RNA sequencing experiments.

Indexed as

Genetic VariationTerminology as TopicAnimalsBiosynthetic PathwaysDEAD-box RNA HelicasesGene Expression RegulationHumansMiceMicroRNAsRibonuclease IIIRNA, Small CytoplasmicRNA, Small InterferingSequence Analysis, RNATranscriptomeZebrafishDEAD-box RNA HelicasesDicer1 protein, mouseDrosha protein, mouseMicroRNAsRibonuclease IIIRNA, Small CytoplasmicRNA, Small InterferingisomiRloop-origin miRNAsmiRNA clustermiRNA-seqmoRnoncoding RNA

Identifiers

PMID26453491
PMCPMC4639415

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.