Evidence map›Paper›PMID 26453377›Full record

ArticleImmunity2015

Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses.

Tangsheng Yi, Jianhua Li, Hsin Chen, Jiaxi Wu, Jinping An, Ying Xu, Yongmei Hu, Clifford A Lowell, Jason G Cyster

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 112 citations in OpenAlex.

  1. Review
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  13. CD47 promotes peripheral T cell survival by preventing dendritic cell-mediated T cell necroptosis.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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  15. Review
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  20. TFrontiers in immunology · 2022
    Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tangsheng YiDepartment of Microbiology and Immunology, University of California, San Francisco and Howard Hughes Medical Institute, CA 94143, USA.
Jianhua LiDepartment of Microbiology and Immunology, University of California, San Francisco and Howard Hughes Medical Institute, CA 94143, USA.
Hsin ChenDepartment of Microbiology and Immunology, University of California, San Francisco and Howard Hughes Medical Institute, CA 94143, USA.
Jiaxi WuDepartment of Microbiology and Immunology, University of California, San Francisco and Howard Hughes Medical Institute, CA 94143, USA.
Jinping AnDepartment of Microbiology and Immunology, University of California, San Francisco and Howard Hughes Medical Institute, CA 94143, USA.
Ying XuDepartment of Microbiology and Immunology, University of California, San Francisco and Howard Hughes Medical Institute, CA 94143, USA.
Yongmei HuDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94141, USA.
Clifford A LowellDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94141, USA.
Jason G CysterDepartment of Microbiology and Immunology, University of California, San Francisco and Howard Hughes Medical Institute, CA 94143, USA. Electronic address: jason.cyster@ucsf.edu.
University of California, San Francisco · USHoward Hughes Medical Institute · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
B LYMPHOCYTE MIGRATION AND HOMEOSTASISR01AI040098 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jason G Cyster · 1997 to 2026
$7.0M
Mechanisms of Neutrophil ActivationR01AI065495 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOWELL, CLIFFORD A · 2005 to 2017
$3.7M
Signaling by Cytoplasmic Tyrosine Kinases in LeukocytesR01AI068150 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOWELL, CLIFFORD A · 2006 to 2016
$3.4M
Beta Lymphocyte Migration and HomeostasisR37AI040098 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 2002 to 2011
$3.2M
Regulation of Innate Immune Signaling by Lyn KinaseR01AI113272 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOWELL, CLIFFORD A · 2015 to 2019
$2.0M
Howard Hughes Medical InstituteNIAID NIH HHS N01 AI040098NIAID NIH HHS R01 AI040098NIAID NIH HHS R01 AI065495NIAID NIH HHS R01 AI068150NIAID NIH HHS R01 AI113272NIDDK NIH HHS P30 DK063720
6 · The paper itself

Abstract

Sheep red blood cells (SRBCs) have long been used as a model antigen for eliciting systemic immune responses, yet the basis for their adjuvant activity has been unknown. Here, we show that SRBCs failed to engage the inhibitory mouse SIRPα receptor on splenic CD4(+) dendritic cells (DCs), and this failure led to DC activation. Removal of the SIRPα ligand, CD47, from self-RBCs was sufficient to convert them into an adjuvant for adaptive immune responses. DC capture of Cd47(-/-) RBCs and DC activation occurred within minutes in a Src-family-kinase- and CD18-integrin-dependent manner. These findings provide an explanation for the adjuvant mechanism of SRBCs and reveal that splenic DCs survey blood cells for missing self-CD47, a process that might contribute to detecting and mounting immune responses against pathogen-infected RBCs.

Indexed as

Adaptive ImmunityAdjuvants, ImmunologicAnimalsBase SequenceCD18 AntigensCD47 AntigenCD4 AntigensCell MovementDendritic CellsErythrocytesIntegrinsMiceMice, Inbred C57BLMice, KnockoutPhagocytosisRadiation ChimeraAdjuvants, ImmunologicCD18 AntigensCD47 AntigenCd47 protein, mouseCD4 AntigensIntegrinsReceptors, ImmunologicRNA, MessengerSirpa protein, mousesrc-Family Kinases

Identifiers

PMID26453377
PMCPMC4618158
OpenAlexW1850049504

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.