ReviewThe Lancet. Infectious diseases2015
Emerging tick-borne infections in mainland China: an increasing public health threat.
Open access · bronzeAbstract readReview
In one paragraph
Review in The Lancet. Infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
182citing papers in PubMed, 6 pooled it
11.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
182 citing papers in PubMed, 6 syntheses or guidelines pooled it, 309 citations in OpenAlex.
- Prevalence and associated factors of Anaplasma, Rickettsia, and Coxiella-related bacteria in ticks in China: A systematic review and meta-analysis.Experimental & applied acarology · 2026Pooled it
- From flyways to foci: a systematic review and meta-analysis on the role of birds in the maintenance and global dispersal of ticks and tick-borne pathogens.Parasites & vectors · 2026Pooled it
- Prevalence of Tick Infection with Bartonella in China: A Review and Meta-analysis.Acta parasitologica · 2024Pooled it
- Systematic Review and Meta-analysis of Lyme Disease Data and Seropositivity for Borrelia burgdorferi, China, 2005‒2020.Emerging infectious diseases · 2022Pooled it
- Global meta-analysis onPathogens and global health · 2022Pooled it
- Distribution ofInternational journal of environmental research and public health · 2021Pooled it
- Dissecting the evolutionary forces shaping codon usage bias in SFTSV from eastern China: Insights from a previously underrepresented region.Virulence · 2026Article
- Establishment and application of a multiplex qPCR panel for multi-host surveillance of tick-Borne pathogens.Emerging microbes & infections · 2026Article
- High-resolution prediction and risk mapping ofiScience · 2026Article
- Complex exposure-response relationships between meteorological factors and severe fever with thrombocytopenia syndrome risk.Tropical medicine and health · 2026Article
- Metagenomic insights into pathogen diversity and public health risk of Haemaphysalis longicornis in Gansu Province of China.PLoS neglected tropical diseases · 2026Article
- Tick-borne viruses: discovery, clinical aspects, influencing factors and control.Nature reviews. Microbiology · 2026Review
- Genomic and evolutionary basis of parthenogenesis in a disease-vector tick species.Nature ecology & evolution · 2026Article
- A rare presentation of clinically diagnosed lyme disease with probable neuroborreliosis, septic shock, and bone marrow suppression: a case report.BMC infectious diseases · 2026Article
- Diversity and Spatiotemporal Atlas of Ticks in the Beijing-Tianjin-Hebei Urban Agglomeration Based on the MaxEnt Model.Veterinary sciences · 2026Article
- First molecular evidence of Rickettsia spp. in Triatoma rubrofasciata: implications for vector ecology and zoonotic transmission.Parasites & vectors · 2026Article
- Metagenomic and serological evidence of emerging tick-borne viruses in livestock, humans, and rats in Pakistan.Virologica Sinica · 2026Article
- Lyme borreliosis.Nature reviews. Disease primers · 2026Review
- Prevalence and Risk Factors ofPathogens (Basel, Switzerland) · 2026Article
- An exploratory study on tick control in the field.Current research in parasitology & vector-borne diseases · 2026Article
122 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 5 institutions in 2 countries.
Li-Qun Fang *State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Kun Liu *State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Xin-Lou LiState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Song LiangState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Yang YangState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Hong-Wu YaoState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Ruo-Xi SunState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Ye SunState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Wan-Jun ChenState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Shu-Qing ZuoState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Mai-Juan MaState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Hao LiState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Jia-Fu JiangState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Wei LiuState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
X Frank YangState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Gregory C GrayState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Peter J KrauseState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Wu-Chun CaoState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China (L-Q Fang PhD, K Liu MS, X-L Li MS, H-W Yao MS, R-X Sun BS, Y Sun BS, W-J Chen BS, S-Q Zuo PhD, M-J Ma PhD, H Li PhD, J-F Jiang PhD, Prof W Liu PhD, Prof W-C Cao PhD); College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA (S Liang PhD, Y Yang PhD); Department of Microbiology and Immunology, Indiana University School of Medicine, Barnhill, IN, USA (Prof X F Yang PhD); Duke University School of Medicine, Durham, NC, USA (Prof G C Gray MD); and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and Department of Medicine and Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA (P J Krause MD).
Institute of Microbiology · CNUniversity of Florida · USDuke University · USIndiana University · USYale University · US
Funding
Understanding Transmission with Integrated Genetic and Epidemiologic InferenceU54GM111274 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BEDFORD, TREVOR BC · 2014 to 2018
$12.5MRegulatory Network of the Lyme Disease PathogenR01AI083640 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI X. Frank Yang · 2009 to 2026
$5.9MNIAID NIH HHS 5R01AI083640NIAID NIH HHS R01 AI083640NIGMS NIH HHS U54 GM111274
Abstract
Since the beginning of the 1980s, 33 emerging tick-borne agents have been identified in mainland China, including eight species of spotted fever group rickettsiae, seven species in the family Anaplasmataceae, six genospecies in the complex Borrelia burgdorferi sensu lato, 11 species of Babesia, and the virus causing severe fever with thrombocytopenia syndrome. In this Review we have mapped the geographical distributions of human cases of infection. 15 of the 33 emerging tick-borne agents have been reported to cause human disease, and their clinical characteristics have been described. The non-specific clinical manifestations caused by tick-borne pathogens present a major diagnostic challenge and most physicians are unfamiliar with the many tick-borne diseases that present with non-specific symptoms in the early stages of the illness. Advances in and application of modern molecular techniques should help with identification of emerging tick-borne pathogens and improve laboratory diagnosis of human infections. We expect that more novel tick-borne infections in ticks and animals will be identified and additional emerging tick-borne diseases in human beings will be discovered.
Indexed as
AnaplasmataceaeAnaplasmataceae InfectionsAnimalsArachnid VectorsBabesiaBabesiosisBorrelia burgdorferi GroupChinaHumansLyme DiseasePublic HealthRickettsiaRickettsia InfectionsTick-Borne DiseasesTicks
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