ArticleThe Journal of cell biology1989
Detection of a specific isoform of alpha-actinin with antisera directed against dystrophin.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- Developmental expression of spectrins in rat skeletal muscle.Molecular biology of the cell · 1998Article
- Small, membrane-bound, alternatively spliced forms of ankyrin 1 associated with the sarcoplasmic reticulum of mammalian skeletal muscle.The Journal of cell biology · 1997Article
- Use of epitope libraries to identify exon-specific monoclonal antibodies for characterization of altered dystrophins in muscular dystrophy.American journal of human genetics · 1993Article
- Monoclonal antibodies for dystrophin analysis. Epitope mapping and improved binding to SDS-treated muscle sections.The Biochemical journal · 1992Article
- Direct visualization of the dystrophin network on skeletal muscle fiber membrane.The Journal of cell biology · 1992Article
- Dystrophin colocalizes with beta-spectrin in distinct subsarcolemmal domains in mammalian skeletal muscle.The Journal of cell biology · 1992Article
- Localization of the DMDL gene-encoded dystrophin-related protein using a panel of nineteen monoclonal antibodies: presence at neuromuscular junctions, in the sarcolemma of dystrophic skeletal muscle, in vascular and other smooth muscles, and in proliferating brain cell lines.The Journal of cell biology · 1991Article
- Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Localization of dystrophin relative to acetylcholine receptor domains in electric tissue and adult and cultured skeletal muscle.The Journal of cell biology · 1991Article
- Dystrophin-glycoprotein complex is highly enriched in isolated skeletal muscle sarcolemma.The Journal of cell biology · 1991Article
- Isolated dystrophin molecules as seen by electron microscopy.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Heterogeneity of dystrophin expression in patients with Duchenne and Becker muscular dystrophy.Acta neuropathologica · 1990Article
- The structure and function of alpha-actinin.Journal of muscle research and cell motility · 1989Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have characterized a protein immunologically related to dystrophin, the protein product of the Duchenne muscular dystrophy gene. We identify this related protein as a fast-twitch glycolytic isoform (mouse extensor digitorum longus-specific) of myofibrillar alpha-actinin. This specific isoform of alpha-actinin exhibits a more restricted pattern of expression in skeletal muscle than fast-twitch-specific isoforms of both myosin and Ca2+-ATPase. Our results provide evidence that dystrophin and myofibrillar alpha-actinin are related proteins, reinforcing the previous data concerning the sequence homologies noted between nonmuscle cytoskeletal alpha-actinin and dystrophin. In addition, we describe the first antisera directed against a specific myofibrillar skeletal muscle isoform of alpha-actinin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.