ArticleThe Journal of cell biology1989
Cell cycle-dependent association of HSP70 with specific cellular proteins.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 143 citations in OpenAlex.
- Exercise training and work task induced metabolic and stress-related mRNA and protein responses in myalgic muscles.BioMed research international · 2013Trial
- Reduced HSP70 expression under mild hypothermia is involved in bovine embryo growth suppression.The Journal of reproduction and development · 2025Article
- The Nuclear and DNA-Associated Molecular Chaperone Network.Cold Spring Harbor perspectives in biology · 2019Review
- CLEC14a-HSP70-1A interaction regulates HSP70-1A-induced angiogenesis.Scientific reports · 2017Article
- Basal and stress-induced Hsp70 are modulated by ataxin-3.Cell stress & chaperones · 2012Article
- Hsp70 architecture: the formation of novel polymeric structures of Hsp70.1 and Hsc70 after proteotoxic stress.PloS one · 2012Article
- The association of CaM and Hsp70 regulates S-phase arrest and apoptosis in a spatially and temporally dependent manner in human cells.Cell stress & chaperones · 2009Article
- Cooperation of salivary protein histatin 3 with heat shock cognate protein 70 relative to the G1/S transition in human gingival fibroblasts.The Journal of biological chemistry · 2009Article
- Hsp70 localizes differently from chaperone Hsc70 in mouse mesoangioblasts under physiological growth conditions.Journal of molecular histology · 2008Article
- Rapid, transient, and dose-dependent expression of hsp70 messenger RNA in the rat brain after morphine treatment.Cell stress & chaperones · 2004Article
- Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70.Cell stress & chaperones · 2004Article
- Bioinformatic analysis of the nucleolus.The Biochemical journal · 2003Review
- Heat shock factor 1-mediated thermotolerance prevents cell death and results in G2/M cell cycle arrest.Cell stress & chaperones · 2001Article
- Chaperones in cell cycle regulation and mitogenic signal transduction: a review.Cell proliferation · 2000Review
- The chaperone function of hsp70 is required for protection against stress-induced apoptosis.Molecular and cellular biology · 2000Article
- Complexes between nascent polypeptides and their molecular chaperones in the cytosol of mammalian cells.Molecular biology of the cell · 1997Article
- The Epstein-Barr virus nuclear antigen leader protein associates with hsp72/hsc73.Journal of virology · 1995Article
- Heat shock induces resistance in rat pancreatic islet cells against nitric oxide, oxygen radicals and streptozotocin toxicity in vitro.The Journal of clinical investigation · 1995Article
- Cytoplasmic HSP70 homologues of pea: differential expression in vegetative and embryonic organs.Plant molecular biology · 1995Article
- In vivo growth of a murine lymphoma cell line alters regulation of expression of HSP72.Molecular and cellular biology · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In asynchronous populations of HeLa cells maintained at control or heat shock temperatures, HSP70 levels and its subcellular distribution exhibit substantial heterogeneity as demonstrated by indirect immunofluorescence with HSP70-specific monoclonal antibodies. Of particular interest is a subpopulation of cells in which the characteristic nuclear accumulation and nucleolar association of HSP70 is not detected after heat shock treatment. This apparent variation in the heat shock response is not observed when synchronized cells are examined. In this study, we demonstrate that three monoclonal antibodies to HSP70, in particular, do not detect nucleolar-localized HSP70 in heat-shocked G2 cells. This is not due to an inability of G2 cells to respond to heat shock as measured by increased HSP70 mRNA and protein synthesis, or due to a lack of accumulation of HSP70 after heat shock in G2. Rather the epitopes recognized by the various antibodies appear to be inaccessible, perhaps due to the association of HSP70 with other proteins. Non-denaturing immunoprecipitations with these HSP70-specific antibodies suggest that HSP70 may interact with other cellular proteins in a cell cycle-dependent manner.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.