ArticleBMC oral health2015
A case report: retigabine induced oral mucosal dyspigmentation of the hard palate.
Article in BMC oral health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 50 citations in OpenAlex.
- Atypical Intra-Oral Lesions in a Young Epileptic Patient: A Case Report.Clinical case reports · 2025Article
- Drug-Induced Pigmentation: A Review.Drugs · 2024Review
- Blue Nail Discoloration: Literature Review and Diagnostic Algorithms.American journal of clinical dermatology · 2023Review
- Acute Treatment with the M-Channel (KNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Chemical modulation of Kv7 potassium channels.RSC medicinal chemistry · 2021Review
- Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, "M-type") KJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Pharmacological Manipulation of KFrontiers in physiology · 2020Review
- Medication-Induced Oral Hyperpigmentation: A Systematic Review.Patient preference and adherence · 2020Review
- In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner.Communications biology · 2019Article
- Ezogabine skin discoloration is reversible after discontinuation.Epilepsy & behavior case reports · 2017Article
- Review
- Adolescent Clinical Development of Ezogabine/Retigabine as Adjunctive Therapy for Partial-Onset Seizures: Pharmacokinetics and Tolerability.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDyspigmentation of the oral mucosa has a multitude of aetiological causes. Retigabine, a new antiepileptic drug, has the potential side effect of inducing a blue/purple pigmentation of the oral mucosa in addition to the skin, lips, nails and retina of the eyes. This article presents a unique case of dyspigmentation present in the oral mucosa of the hard palate which has previously been unreported in the dental literature. CASE PRESENTATION: A 70 year old white male presented to a secondary care oral surgery department with an unusual asymptomatic pigmented lesion present in the hard palate of the oral cavity. The pigmentation was remarkable for its distinct blue/purple colouration which was associated with a similar discolouration of the nail beds of the hands. This is believed to be a side effect of the anti-epileptic medication retigabine.
conclusionThe dental profession and wider healthcare community should be made fully aware of the potential side effect of oral dyspigmentation associated with the novel anti-epileptic medication retigabine. Enhanced knowledge of the causative role of retigabine in dyspigementation of the oral mucosa will allow the practitioner to make an appropriate diagnosis. As far the authors are aware this is reaction is unreported in the dental literature and should be disseminated to the wider oral health professional's community.
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