ArticleApplied and environmental microbiology2016
The Siderophore Metabolome of Azotobacter vinelandii.
Article in Applied and environmental microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 86 citations in OpenAlex.
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- Inverse stable isotope labeling (InverSIL) links predicted catecholate siderophore gene clusters to their products in diverse bacteria.bioRxiv : the preprint server for biology · 2025Article
- Genome-Guided Metabolomic Profiling of Peptaibol-ProducingInternational journal of molecular sciences · 2025Article
- Ion Mobility-Coupled Mass Spectrometry for Metallophore Detection.Journal of natural products · 2025Article
- Phenotypic and Genomic Characterization ofLife (Basel, Switzerland) · 2025Article
- Degradation of catecholate, hydroxamate, and carboxylate model siderophores by extracellular enzymes.PloS one · 2025Article
- Insights into the genome of Azotobacter sp. strain CWF10, isolated from an agricultural field in Central India.Access microbiology · 2025Article
- Microbiome-volatile metabolome analysis reveals aroma regulation driven by microbial niche competition in Jinggang honey pomelo wine.Frontiers in microbiology · 2025Article
- Genomic, LC-MS, and FTIR Analysis of Plant Probiotic Potential of Bacillus albus for Managing Xanthomonas oryzae via Different Modes of Application in Rice (Oryza sativa L.).Probiotics and antimicrobial proteins · 2024Article
- Implications of bacteria‒bacteria interactions within the plant microbiota for plant health and productivity.Journal of Zhejiang University. Science. B · 2024Review
- LFQRatio: A Normalization Method to Decipher Quantitative Proteome Changes in Microbial Coculture Systems.Journal of proteome research · 2024Article
- Inactivation of siderophore iron-chelating moieties by the fungal wheat root symbiont Pyrenophora biseptata.Environmental microbiology reports · 2024Article
- Production of the siderophore lysochelin in rich media through maltose-promoted high-density growth ofFrontiers in microbiology · 2024Article
- Iron Homeostasis inBiology · 2023Review
- Bacterial Siderophores: Classification, Biosynthesis, Perspectives of Use in Agriculture.Plants (Basel, Switzerland) · 2022Review
- Perspective on the biotechnological production of bacterial siderophores and their use.Applied microbiology and biotechnology · 2022Review
- Structure of New Ferroverdins Recruiting Unconventional Ferrous Iron Chelating Agents.Biomolecules · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we performed a detailed characterization of the siderophore metabolome, or "chelome," of the agriculturally important and widely studied model organism Azotobacter vinelandii. Using a new high-resolution liquid chromatography-mass spectrometry (LC-MS) approach, we found over 35 metal-binding secondary metabolites, indicative of a vast chelome in A. vinelandii. These include vibrioferrin, a siderophore previously observed only in marine bacteria. Quantitative analyses of siderophore production during diazotrophic growth with different sources and availabilities of Fe showed that, under all tested conditions, vibrioferrin was present at the highest concentration of all siderophores and suggested new roles for vibrioferrin in the soil environment. Bioinformatic searches confirmed the capacity for vibrioferrin production in Azotobacter spp. and other bacteria spanning multiple phyla, habitats, and lifestyles. Moreover, our studies revealed a large number of previously unreported derivatives of all known A. vinelandii siderophores and rationalized their origins based on genomic analyses, with implications for siderophore diversity and evolution. Together, these insights provide clues as to why A. vinelandii harbors multiple siderophore biosynthesis gene clusters. Coupled with the growing evidence for alternative functions of siderophores, the vast chelome in A. vinelandii may be explained by multiple, disparate evolutionary pressures that act on siderophore production.
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