Evidence map›Paper›PMID 26452427›Full record

ReviewClinical therapeutics2015

Personal Protective Equipment: Protecting Health Care Providers in an Ebola Outbreak.

William A Fischer, David Weber, David A Wohl

Abstract readReview
In one paragraph

Review in Clinical therapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

William A Fischer *Division of Pulmonary and Critical Care Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
David Weber *Division of Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
David A Wohl *Division of Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

Funding

North Carolina Translational & Clinical Sciences Institute (NC TraCS)KL2TR001109 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$5.7M
Mentoring New Investigators in Criminal Justice HIV Prevention and TreatmentK24DA037101 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WOHL, DAVID A · 2014 to 2018
$911k
The Effect of Aging on LAIV Replication in Human Nasal Epithelial CellsR03AG045088 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FISCHER, WILLIAM · 2013 to 2014
$152k
NCATS NIH HHS KL2 TR001109NCATS NIH HHS KL2TR001109NIA NIH HHS R03 AG045088NIA NIH HHS R03AG045088NIDA NIH HHS K24 DA037101
6 · The paper itself

Abstract

purposeThe recent Ebola epidemic that devastated West Africa has infected and killed more health care providers than any other outbreak in the history of this virus. An improved understanding of pathogen transmission and the institution of strategies to protect health care providers against infection are needed in infectious disease outbreaks. This review connects what is known about Ebola virus transmission with personal protective equipment (PPE) designed to arrest nosocomial transmission.

methodsArticles pertaining to filovirus transmission and PPE in filovirus outbreaks were reviewed and findings are presented. In addition, studies that evaluated PPE and donning and doffing strategies are presented.

findingsPPE is one step in a comprehensive infection prevention and control strategy that is required to protect health care providers. Given that the Ebola virus is primarily transmitted through direct contact of mucous membranes and cuts in the skin with infected patients and/or their bodily fluids, it is necessary to cover these potential portals of infection with PPE as part of a structured and instructed donning and doffing procedure. IMPLICATIONS: Current recommendations about PPE and the donning and doffing processes are based on anecdotal experience. However, the use of non-human viruses can help provide evidence-based guidelines on both PPE and donning and doffing processes.

Indexed as

Personal Protective EquipmentCross InfectionDisease OutbreaksEbolavirusFemaleHealth PersonnelHemorrhagic Fever, EbolaHumansEbolainfection prevention and controloutbreakpersonal protective equipmenttransmission

Identifiers

PMID26452427
PMCPMC4661082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.