Evidence map›Paper›PMID 26452359›Full record

ArticleMolecular neurobiology2016

Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum.

Rafael Franco, Verònica Casadó-Anguera, Ana Muñoz, Milos Petrovic, Gemma Navarro, Estefanía Moreno, José Luis Lanciego, José Luis Labandeira-García, Antoni Cortés, Vicent Casadó

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Nicotine Effects on White Matter Microstructure in Young Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2019
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Rafael FrancoCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain. rfranco123@gmail.com.
Verònica Casadó-AngueraCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.
Ana MuñozCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.
Milos PetrovicSchool of Pharmacy and Biomedical Sciences, University of Central Lancashire, PR1 2HE, Preston, UK.
Gemma NavarroCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.
Estefanía MorenoCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.
José Luis LanciegoCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.
José Luis Labandeira-GarcíaCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.
Antoni CortésCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.
Vicent CasadóCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.
Biomedical Research Networking Center on Neurodegenerative Diseases · ESUniversitat de Barcelona · ESCzech Academy of Sciences, Institute of Physiology · CZInstitut de Biologia Molecular de Barcelona · ESInstituto de Salud Carlos III · ESUniversidad de Navarra · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dopamine receptors in striatum are important for healthy brain functioning and are the target of levodopa-based therapy in Parkinson's disease. Lateralization of dopaminergic neurotransmission in striata from different hemispheres occurs in patients, but also in healthy individuals. Our data show that the affinity of dopamine binding to dopamine D1 receptors is significantly higher in left than in right striatum. Analysis of data from radioligand binding to striatal samples from naïve, 6-hydroxydopamine lesioned, levodopa-treated and levodopa-induced dyskinetic rats shows differential receptor structure and gives hints on the causes of right/left lateralization of dopamine binding to striatal D1 receptors. Moreover, binding data showed loss of lateralization in levodopa (L-DOPA)-induced dyskinetic rats.

Indexed as

Functional Laterality2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAnimalsBenzazepinesCorpus StriatumDopamineDyskinesia, Drug-InducedMaleRats, WistarReceptors, Dopamine D1Receptors, Dopamine D32,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineBenzazepinesDopamineReceptors, Dopamine D1Receptors, Dopamine D3SCH 233906-hydroxydopamineBasal gangliaCooperativity indexDyskinesiaG-protein-coupled receptor dimerLateralization

Identifiers

PMID26452359
OpenAlexW1828405096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.