Evidence map›Paper›PMID 26452162›Full record

Trial reportPloS one2015

Transection Speed and Impact on Perioperative Inflammatory Response - A Randomized Controlled Trial Comparing Stapler Hepatectomy and CUSA Resection.

Christoph Schwarz, Daniel A Klaus, Bianca Tudor, Edith Fleischmann, Thomas Wekerle, Georg Roth, Martin Bodingbauer, Klaus Kaczirek

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01785212 (The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01785212 nacompletednot on this map

The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver

TypeinterventionalSponsorMedical University of ViennaRan2013 to 2015Enrolled40ConditionsLiver Neoplasms, Liver Metastasis, Liver Hemangioma, Echinococcosis, HepaticArmsStapler, CUSA (Cavitron ultrasonic aspirator, Valleylab, Boulder, CO)
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Technical Aspects of Stapled Hepatectomy in Liver Surgery: How We Do It.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christoph SchwarzDept. of Surgery, Div. of General Surgery, Medical University of Vienna, Vienna, Austria; Section of Transplantation Immunology, Dept. of Surgery, Medical University of Vienna, Vienna, Austria.
Daniel A KlausDept. of Anesthesiology, General Intensive Care and Pain Medicine, Medical University of Vienna, Vienna, Austria.
Bianca TudorDept. of Anesthesiology, General Intensive Care and Pain Medicine, Medical University of Vienna, Vienna, Austria.
Edith FleischmannDept. of Anesthesiology, General Intensive Care and Pain Medicine, Medical University of Vienna, Vienna, Austria.
Thomas WekerleSection of Transplantation Immunology, Dept. of Surgery, Medical University of Vienna, Vienna, Austria.
Georg RothDept. of Anesthesiology, General Intensive Care and Pain Medicine, Medical University of Vienna, Vienna, Austria.
Martin BodingbauerDept. of Surgery, Div. of General Surgery, Medical University of Vienna, Vienna, Austria.
Klaus KaczirekDept. of Surgery, Div. of General Surgery, Medical University of Vienna, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParenchymal transection represents a crucial step during liver surgery and many different techniques have been described so far. Stapler resection is supposed to be faster than CUSA resection. However, whether speed impacts on the inflammatory response in patients undergoing liver resection (LR) remains unclear. MATERIALS AND

methodsThis is a randomized controlled trial including 40 patients undergoing anatomical LR. Primary endpoint was transection speed (cm2/min). Secondary endpoints included the perioperative change of pro- and anti-inflammatory cytokines, overall surgery duration, length of hospital stay, morbidity and mortality.

resultsMean transection speed was significantly higher in patients undergoing stapler hepatectomy compared to CUSA resection (CUSA: 1 (0.4) cm2/min vs. Stapler: 10.8 (6.1) cm2/min; p<0.0001). Analyzing the impact of surgery duration on inflammatory response revealed a significant correlation between IL-6 levels measured at the end of surgery and the overall length of surgery (p<0.0001, r = 0.6188). Patients undergoing CUSA LR had significantly higher increase of interleukin-6 (IL-6) after parenchymal transection compared to patients with stapler hepatectomy in the portal and hepatic veins, respectively (p = 0.028; p = 0.044). C-reactive protein levels on the first post-operative day were significantly lower in the stapler cohort (p = 0.010). There was a trend towards a reduced overall surgery time in patients with stapler LR, especially in the subgroup of patients undergoing minor hepatectomies (p = 0.020).

conclusionsLiver resection using staplers is fast, safe and suggests a diminished inflammatory response probably due to a decreased parenchymal transection time.

trial registrationClinicalTrials.gov NCT01785212.

Indexed as

Operative TimePerioperative PeriodAgedFemaleHepatectomyHumansInflammationLiverMaleMiddle AgedTreatment Outcome

Identifiers

PMID26452162
PMCPMC4599945

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.