ArticlePLoS neglected tropical diseases2015
Overlooked Risk for Chronic Kidney Disease after Leptospiral Infection: A Population-Based Survey and Epidemiological Cohort Evidence.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Heterogeneity in diagnostic criteria for chronic kidney disease of undetermined etiology (CKDu): a systematic review of the literature.BMC nephrology · 2025Pooled it
- Pooled it
- Environmental risk factors for chronic kidney disease of non-traditional causes in tropical coastal areas: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2025Pooled it
- Leptospirosis as a risk factor for chronic kidney disease: A systematic review of observational studies.PLoS neglected tropical diseases · 2019Pooled it
- Review
- Effects of social determinants of health on the landscape of kidney disease.Nature reviews. Nephrology · 2026Review
- Leptospirosis in Central Romania: A 17-Year Single-Center Cohort Study of Hospitalized Adults.Microorganisms · 2026Article
- Immediate or delayed initiation of renal replacement therapy in patients with leptospirosis and acute kidney injury: a target trial emulation.Annals of intensive care · 2025Article
- Leptospirosis-Improving Healthcare Outcomes for a Neglected Tropical Disease.Open forum infectious diseases · 2025Review
- Design and set-up of the leptospirosis registryFrontiers in public health · 2025Article
- Uncovering latent infections in kidneys: A novel molecular approach for differentialCurrent research in microbial sciences · 2025Article
- Environmental Change, Changing Biodiversity, and Infections-Lessons for Kidney Health Community.Kidney international reports · 2023Review
- Associations of air pollutant concentrations with longitudinal kidney function changes in patients with chronic kidney disease.Scientific reports · 2023Article
- Kidney Injury Biomarkers in Leptospirosis.Revista da Sociedade Brasileira de Medicina Tropical · 2023Review
- Long-Term Outcome of Leptospirosis Infection with Acute Kidney Injury.Biomedicines · 2022Article
- Integrated Metabolomic and Transcriptomic Analysis of Acute Kidney Injury Caused byPathogens (Basel, Switzerland) · 2022Article
- Implication of the IL-10-Expression Signature in the Pathogenicity ofMicrobiology spectrum · 2022Article
- Insight into the Structure, Functions, and Dynamics of theMembranes · 2022Review
- Understanding the Renal Fibrotic Process in Leptospirosis.International journal of molecular sciences · 2021Review
- Correlation between renal distribution of leptospires during the acute phase and chronic renal dysfunction in a hamster model of infection with Leptospira interrogans.PLoS neglected tropical diseases · 2021Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeptospirosis is the most widespread zoonosis. Chronic human infection and asymptomatic colonization have been reported. However, renal involvement in those with leptospira chronic exposure remains undetermined. METHODS AND
findingsIn 2007, a multistage sampling survey for chronic kidney disease (CKD) was conducted in a southern county of Taiwan, an area with a high prevalence of dialysis. Additionally, an independent cohort of 88 participants from a leptospira-endemic town was followed for two years after a flooding in 2009. Risks of CKD, stages of CKD, associated risk factors as well as kidney injury markers were compared among adults with anti-leptospira antibody as defined by titers of microscopic agglutination test (MAT). Of 3045 survey participants, the individuals with previous leptospira exposure disclosed a lower level of eGFR (98.3 ± 0.4 vs 100.8 ± 0.6 ml/min per 1.73 m2, P < 0.001) and a higher percentage of CKD, particularly at stage 3a-5 (14.4% vs 8.5%), than those without leptospira exposure. Multivariable linear regression analyses indicated the association of leptospiral infection and lower eGFR (95% CI -4.15 to -1.93, P < 0.001). In a leptospiral endemic town, subjects with a MAT titer ≥ 400 showed a decreased eGFR and higher urinary kidney injury molecule-1 creatinine ratio (KIM1/Cr) level as compared with those having lower titers of MAT (P < 0.05). Furthermore, two participants with persistently high MAT titers had positive urine leptospira DNA and deteriorating renal function. CONCLUSIONS AND SIGNIFICANCE: Our data are the first to show that chronic human exposure of leptospirosis is associated significantly with prevalence and severity of CKD and may lead to deterioration of renal function. This study also shed light on the search of underlying factors in areas experiencing CKD of unknown aetiology (CKDu) such as Mesoamerican Nephropathy.
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