ArticleeLife2015
A molecular mechanism underlying gustatory memory trace for an association in the insular cortex.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Correlation Between theEpidemiologia (Basel, Switzerland) · 2026Article
- Learning depends on the information conveyed by temporal relationships between events and is reflected in the dopamine response to cues.Science advances · 2024Article
- Uncovering Interoceptive Human Insular Lobe Function through Intraoperative Cortical Stimulation-A Review.Brain sciences · 2024Review
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- Article
- Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly.eLife · 2021Article
- Article
- Taste Processing: Insights from Animal Models.Molecules (Basel, Switzerland) · 2020Review
- The anterior insular cortex unilaterally controls feeding in response to aversive visceral stimuli in mice.Nature communications · 2020Article
- Activity of Insula to Basolateral Amygdala Projecting Neurons is Necessary and Sufficient for Taste Valence Representation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The role of the gustatory cortex in incidental experience-evoked enhancement of later taste learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- The effects of amygdala and cortical inactivation on taste neophobia.Neurobiology of learning and memory · 2018Article
- Calcium-stimulated adenylyl cyclase subtype 1 (AC1) contributes to LTP in the insular cortex of adult mice.Heliyon · 2017Article
- Memory trace reactivation and behavioral response during retrieval are differentially modulated by amygdalar glutamate receptors activity: interaction between amygdala and insular cortex.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- CaMKII Requirement forFrontiers in pharmacology · 2017Article
- The Insula and Taste Learning.Frontiers in molecular neuroscience · 2017Review
- ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion.Nature communications · 2016Article
- Fluid consumption and taste novelty determines transcription temporal dynamics in the gustatory cortex.Molecular brain · 2016Article
Corrections and comments
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Events separated in time are associatively learned in trace conditioning, recruiting more neuronal circuits and molecular mechanisms than in delay conditioning. However, it remains unknown whether a given sensory memory trace is being maintained as a unitary item to associate. Here, we used conditioned taste aversion learning in the rat model, wherein animals associate a novel taste with visceral nausea, and demonstrate that there are two parallel memory traces of a novel taste: a short-duration robust trace, lasting approximately 3 hr, and a parallel long-duration weak one, lasting up to 8 hr, and dependent on the strong trace for its formation. Moreover, only the early robust trace is maintained by a NMDAR-dependent CaMKII- AMPAR pathway in the insular cortex. These findings suggest that a memory trace undergoes rapid modifications, and that the mechanisms underlying trace associative learning differ when items in the memory are experienced at different time points.
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