Evidence map›Paper›PMID 26451980›Full record

ReviewCurrent opinion in genetics & development2015

The language of the protein universe.

Andrea Scaiewicz, Michael Levitt

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Contrastive learning in protein language space predicts interactions between drugs and protein targets.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Quantitative In Silico Evaluation of Allergenic Proteins fromCurrent issues in molecular biology · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Grammar of protein domain architectures.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  9. Review
  10. Unique function words characterize genomic proteins.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andrea ScaiewiczDepartment of Structural Biology, Stanford University, Stanford, CA 94305-5126, United States.
Michael LevittDepartment of Structural Biology, Stanford University, Stanford, CA 94305-5126, United States. Electronic address: michael.levitt@stanford.edu.

Funding

Accurate Molecular Modeling in Structural GenomicsR01GM063817 · NIGMS · STANFORD UNIVERSITY · PI LEVITT, MICHAEL · 2001 to 2016
$5.0M
NIGMS NIH HHS GM063817NIGMS NIH HHS R01 GM063817
6 · The paper itself

Abstract

Proteins, the main cell machinery which play a major role in nearly every cellular process, have always been a central focus in biology. We live in the post-genomic era, and inferring information from massive data sets is a steadily growing universal challenge. The increasing availability of fully sequenced genomes can be regarded as the 'Rosetta Stone' of the protein universe, allowing the understanding of genomes and their evolution, just as the original Rosetta Stone allowed Champollion to decipher the ancient Egyptian hieroglyphics. In this review, we consider aspects of the protein domain architectures repertoire that are closely related to those of human languages and aim to provide some insights about the language of proteins.

Indexed as

Amino Acid SequenceLanguageProtein Structure, TertiaryComputational BiologyEvolution, MolecularGenomeHumansProteinsProteins

Identifiers

PMID26451980
PMCPMC4695241

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.