ArticleEndocrinology2016
Thyroid Hormone Receptor α Plays an Essential Role in Male Skeletal Muscle Myoblast Proliferation, Differentiation, and Response to Injury.
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Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
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Who cites it
35 citing papers in PubMed, 51 citations in OpenAlex.
- Ageing-Dependent Thyroid Hormone Receptor α Reduction Activates IP3R1-Meditated CaCell proliferation · 2026Article
- Hypothyroidism impairs skeletal muscle regeneration after injury by altering myogenic and nonmyogenic pathways.JCI insight · 2026Article
- Targeting nuclear receptors in muscular dystrophies and regenerative myogenesis.Frontiers in cell and developmental biology · 2026Review
- Beyond hormone deficiency: a framework for endocrine-immune-niche integration in aging skeletal muscle regeneration.Frontiers in immunology · 2026Review
- Functional role of THRAP3 in modulating thyroid hormone-mediated gene networks in C2C12 myotubes.PloS one · 2026Article
- RNA-seq and ChIP-seq unveils thyroid hormone receptor α deficiency affects skeletal muscle myoblast proliferation and differentiation via Col6a1 during aging.Journal of muscle research and cell motility · 2025Article
- Polymyositis-like hypothyroid myopathy: diagnostic challenges and therapeutic outcomes in a case series.Clinical and experimental medicine · 2025Article
- Review
- Complementary and additive functions of TRα and TRβ during intestinal remodeling as revealed by ChIP-Seq analysis on wild type and TR knockout animals.General and comparative endocrinology · 2025Article
- Body composition changes in patients with differentiated thyroid cancer after iodine-131 treatment and short-term levothyroxine replacement and suppression therapy.Hormones (Athens, Greece) · 2024Article
- Nuclear receptors as potential therapeutic targets in peripheral arterial disease and related myopathy.The FEBS journal · 2023Review
- Thyroid Hormone Regulates the Lipid Content of Muscle Fibers, Thus Affecting Physical Exercise Performance.International journal of molecular sciences · 2023Article
- Article
- Low Inflammatory Stimulus Increases D2 Activity and Modulates Thyroid Hormone Metabolism during Myogenesis In Vitro.Metabolites · 2022Article
- Maternal Exercise Before and During Pregnancy Facilitates Embryonic Myogenesis by Enhancing Thyroid Hormone Signaling.Thyroid : official journal of the American Thyroid Association · 2022Article
- Thyroid Hormone Receptor Isoforms Alpha and Beta Play Convergent Roles in Muscle Physiology and Metabolic Regulation.Metabolites · 2022Article
- Proteomic Analysis of the Intestinal Resistance to Thyroid Hormone Mouse Model With Thyroid Hormone Receptor Alpha Mutations.Frontiers in endocrinology · 2022Article
- Smoothelin-Like Protein 1 Regulates the Thyroid Hormone-Induced Homeostasis and Remodeling of C2C12 Cells via the Modulation of Myosin Phosphatase.International journal of molecular sciences · 2021Article
- Persistent COUP-TFII expression underlies the myopathy and impaired muscle regeneration observed in resistance to thyroid hormone-alpha.Scientific reports · 2021Article
- Characterization of Skeletal Muscle Endocrine Control in an In Vitro Model of Myogenesis.Calcified tissue international · 2020Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Anna MilanesiDepartment of Medicine (A.M., Y.-Y.L., A.Y., G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, and Departments of Medicine and Physiology, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California 90073; Department of Neurosurgery (J.-W.L., N.-H.K., A.K., V.C.), Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Urology (S.S., N.T., L.P.), Children's Hospital Los Angeles, University of Southern California, Los Angeles, California 90027; and National Cancer Institute (S.C.), Bethesda, Maryland 20892.
Jang-Won LeeDepartment of Medicine (A.M., Y.-Y.L., A.Y., G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, and Departments of Medicine and Physiology, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California 90073; Department of Neurosurgery (J.-W.L., N.-H.K., A.K., V.C.), Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Urology (S.S., N.T., L.P.), Children's Hospital Los Angeles, University of Southern California, Los Angeles, California 90027; and National Cancer Institute (S.C.), Bethesda, Maryland 20892.
Nam-Ho KimDepartment of Medicine (A.M., Y.-Y.L., A.Y., G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, and Departments of Medicine and Physiology, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California 90073; Department of Neurosurgery (J.-W.L., N.-H.K., A.K., V.C.), Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Urology (S.S., N.T., L.P.), Children's Hospital Los Angeles, University of Southern California, Los Angeles, California 90027; and National Cancer Institute (S.C.), Bethesda, Maryland 20892.
Yan-Yun LiuDepartment of Medicine (A.M., Y.-Y.L., A.Y., G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, and Departments of Medicine and Physiology, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California 90073; Department of Neurosurgery (J.-W.L., N.-H.K., A.K., V.C.), Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Urology (S.S., N.T., L.P.), Children's Hospital Los Angeles, University of Southern California, Los Angeles, California 90027; and National Cancer Institute (S.C.), Bethesda, Maryland 20892.
An YangDepartment of Medicine (A.M., Y.-Y.L., A.Y., G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, and Departments of Medicine and Physiology, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California 90073; Department of Neurosurgery (J.-W.L., N.-H.K., A.K., V.C.), Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Urology (S.S., N.T., L.P.), Children's Hospital Los Angeles, University of Southern California, Los Angeles, California 90027; and National Cancer Institute (S.C.), Bethesda, Maryland 20892.
Sargis SedrakyanDepartment of Medicine (A.M., Y.-Y.L., A.Y., G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, and Departments of Medicine and Physiology, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California 90073; Department of Neurosurgery (J.-W.L., N.-H.K., A.K., V.C.), Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Urology (S.S., N.T., L.P.), Children's Hospital Los Angeles, University of Southern California, Los Angeles, California 90027; and National Cancer Institute (S.C.), Bethesda, Maryland 20892.
Andrew KahngDepartment of Medicine (A.M., Y.-Y.L., A.Y., G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, and Departments of Medicine and Physiology, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California 90073; Department of Neurosurgery (J.-W.L., N.-H.K., A.K., V.C.), Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Urology (S.S., N.T., L.P.), Children's Hospital Los Angeles, University of Southern California, Los Angeles, California 90027; and National Cancer Institute (S.C.), Bethesda, Maryland 20892.
Vanessa CervantesDepartment of Medicine (A.M., Y.-Y.L., A.Y., G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, and Departments of Medicine and Physiology, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California 90073; Department of Neurosurgery (J.-W.L., N.-H.K., A.K., V.C.), Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Urology (S.S., N.T., L.P.), Children's Hospital Los Angeles, University of Southern California, Los Angeles, California 90027; and National Cancer Institute (S.C.), Bethesda, Maryland 20892.
Nikita TripuraneniDepartment of Medicine (A.M., Y.-Y.L., A.Y., G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, and Departments of Medicine and Physiology, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California 90073; Department of Neurosurgery (J.-W.L., N.-H.K., A.K., V.C.), Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Urology (S.S., N.T., L.P.), Children's Hospital Los Angeles, University of Southern California, Los Angeles, California 90027; and National Cancer Institute (S.C.), Bethesda, Maryland 20892.
Sheue-yann ChengDepartment of Medicine (A.M., Y.-Y.L., A.Y., G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, and Departments of Medicine and Physiology, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California 90073; Department of Neurosurgery (J.-W.L., N.-H.K., A.K., V.C.), Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Urology (S.S., N.T., L.P.), Children's Hospital Los Angeles, University of Southern California, Los Angeles, California 90027; and National Cancer Institute (S.C.), Bethesda, Maryland 20892.
Laura PerinDepartment of Medicine (A.M., Y.-Y.L., A.Y., G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, and Departments of Medicine and Physiology, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California 90073; Department of Neurosurgery (J.-W.L., N.-H.K., A.K., V.C.), Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Urology (S.S., N.T., L.P.), Children's Hospital Los Angeles, University of Southern California, Los Angeles, California 90027; and National Cancer Institute (S.C.), Bethesda, Maryland 20892.
Gregory A BrentDepartment of Medicine (A.M., Y.-Y.L., A.Y., G.A.B.), Veterans Affairs Greater Los Angeles Healthcare System, and Departments of Medicine and Physiology, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California 90073; Department of Neurosurgery (J.-W.L., N.-H.K., A.K., V.C.), Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Urology (S.S., N.T., L.P.), Children's Hospital Los Angeles, University of Southern California, Los Angeles, California 90027; and National Cancer Institute (S.C.), Bethesda, Maryland 20892.
Cedars-Sinai Medical Center · USVA Greater Los Angeles Healthcare System · USUniversity of Southern California · USChildren's Hospital of Los Angeles · USNational Cancer Institute · USUniversity of California, Los Angeles · US
Funding
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MThyroid Hormone Receptors in Health and DiseaseZIABC008752 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHENG, SHEUE-YANN · 2009 to 2025
$12.9MThyroid Hormone Receptor Isoform-Specific ActionsR01DK098576 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRENT, GREGORY A · 2014 to 2017
$1.3MThyroid Hormone Receptor Isoforms in Skeletal MuscleK08DK097295 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MILANESI, ANNA · 2013 to 2016
$648kThyroid Hormone and Retinoic Acid Regulation of Gene ExpressionI01BX001966 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI BRENT, GREGORY A · 2014 to 2025
–BLRD VA I01 BX001966NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NIDDK NIH HHS 1K08DK097295NIDDK NIH HHS K08 DK097295NIDDK NIH HHS R01 DK098576NIDDK NIH HHS R01DK98576
Abstract
Thyroid hormone plays an essential role in myogenesis, the process required for skeletal muscle development and repair, although the mechanisms have not been established. Skeletal muscle develops from the fusion of precursor myoblasts into myofibers. We have used the C2C12 skeletal muscle myoblast cell line, primary myoblasts, and mouse models of resistance to thyroid hormone (RTH) α and β, to determine the role of thyroid hormone in the regulation of myoblast differentiation. T3, which activates thyroid hormone receptor (TR) α and β, increased myoblast differentiation whereas GC1, a selective TRβ agonist, was minimally effective. Genetic approaches confirmed that TRα plays an important role in normal myoblast proliferation and differentiation and acts through the Wnt/β-catenin signaling pathway. Myoblasts with TRα knockdown, or derived from RTH-TRα PV (a frame-shift mutation) mice, displayed reduced proliferation and myogenic differentiation. Moreover, skeletal muscle from the TRα1PV mutant mouse had impaired in vivo regeneration after injury. RTH-TRβ PV mutant mouse model skeletal muscle and derived primary myoblasts did not have altered proliferation, myogenic differentiation, or response to injury when compared with control. In conclusion, TRα plays an essential role in myoblast homeostasis and provides a potential therapeutic target to enhance skeletal muscle regeneration.
Indexed as
Muscle DevelopmentRegenerationAcetatesAnimalsCell LineCell ProliferationCells, CulturedDrug ResistanceFrameshift MutationGene Expression RegulationMaleMiceMice, Inbred C57BLMice, Mutant StrainsMuscle, SkeletalMyoblasts, SkeletalAcetatesGC 1 compoundPhenolsThyroid Hormone Receptors alphaThyroid Hormone Receptors betaTriiodothyronine
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