Evidence map›Paper›PMID 26451497›Full record

ReviewCurrent opinion in genetics & development2015

The cellular basis of hybrid dysgenesis and Stellate regulation in Drosophila.

Colin D Malone, Ruth Lehmann, Felipe Karam Teixeira

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
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  11. Epigenetics and genome stability.Mammalian genome : official journal of the International Mammalian Genome Society · 2020
    Review
  12. Article
  13. Article
  14. Review
  15. Article
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  17. Article
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  19. Article
  20. dFmr1 Plays Roles in Small RNA Pathways of Drosophila melanogaster.International journal of molecular sciences · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Colin D MaloneHoward Hughes Medical Institute and Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA. Electronic address: Colin.Dean.Malone@gmail.com.
Ruth LehmannHoward Hughes Medical Institute and Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
Felipe Karam TeixeiraHoward Hughes Medical Institute and Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA. Electronic address: Felipe.Teixeira@med.nyu.edu.

Funding

Germ Cell Migration in Drosophila.R01HD041900 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LEHMANN, RUTH · 2001 to 2012
$3.5M
Germ Cell Migration in Drosophila.R37HD041900 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LEHMANN, RUTH · 2013 to 2021
$2.6M
Howard Hughes Medical InstituteNICHD NIH HHS R01/R37HD41900NICHD NIH HHS R37 HD041900
6 · The paper itself

Abstract

During normal tissue development, the accumulation of unrepaired cellular and genomic damage can impair growth and ultimately leads to death. To preserve cellular integrity, cells employ a number of defense mechanisms including molecular checkpoints, during which development is halted while dedicated pathways attempt repair. This process is most critical in germline tissues where cellular damage directly threatens an organism's reproductive capacity and offspring viability. In the fruit fly, Drosophila melanogaster, germline development has been extensively studied for over a century and the breadth of our knowledge has flourished in the genomics age. Intriguingly, several peculiar phenomena that trigger catastrophic germline damage described decades ago, still endure only a partial understanding of the underlying molecular causes. A deeper reexamination using new molecular and genetic tools may greatly benefit our understanding of host system biology. Among these, and the focus of this concise review, are hybrid dysgenesis and an intragenomic conflict that pits the X and Y sex chromosomes against each other.

Indexed as

AnimalsDrosophila melanogasterDrosophila ProteinsGerm CellsGonadal DysgenesisProtein KinasesSex ChromosomesSystems BiologyDrosophila ProteinsProtein KinasesSte protein, Drosophila

Identifiers

PMID26451497
PMCPMC4674331

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.