Evidence map›Paper›PMID 26451477›Full record

ArticleCell2015

Fleeting Amyloid-like Forms of Rim4 Ensure Meiotic Fidelity.

Alice Flynn Ford, James Shorter

Abstract readComment
In one paragraph

Article in Cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. The molecular language of membraneless organelles.The Journal of biological chemistry · 2019
    Review
  3. Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies.Cold Spring Harbor perspectives in medicine · 2017
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Alice Flynn FordDepartment of Biochemistry and Biophysics, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA 19104, USA; Neuroscience Graduate Group, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA 19104, USA.
James ShorterDepartment of Biochemistry and Biophysics, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA 19104, USA; Neuroscience Graduate Group, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: jshorter@mail.med.upenn.edu.

Funding

Defining the mechanistic basis of a prion disaggregaseR01GM099836 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SHORTER, JAMES · 2013 to 2024
$3.9M
NIGMS NIH HHS R01 GM099836
6 · The paper itself

Abstract

Berchowitz et al. establish that transient amyloid-like forms of Rim4, a yeast RNA-binding protein with a predicted prion domain, translationally repress cyclin CLB3 in meiosis I, thereby ensuring homologous chromosome segregation. These findings suggest that prion domains might enable formation of tightly regulated amyloid-like effectors in diverse functional settings.

Indexed as

GametogenesisProtein AggregatesAnimalsMaleRNA-Binding ProteinsSaccharomyces cerevisiae ProteinsProtein AggregatesRNA-Binding ProteinsSaccharomyces cerevisiae Proteins

Identifiers

PMID26451477
PMCPMC4653133

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.