ArticleTissue barriers
Physiological extracellular electrical signals guide and orient the polarity of gut epithelial cells.
Article in Tissue barriers. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem.Advanced healthcare materials · 2026Article
- Migration of Human Renal Tubular Epithelial Cells in Response to Physiological Electric Signals.Frontiers in cell and developmental biology · 2021Article
- Platelet Deposition Onto Vascular Wall Regulated by Electrical Signal.Frontiers in physiology · 2021Article
- Reversing the direction of galvanotaxis with controlled increases in boundary layer viscosity.Physical biology · 2018Article
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Authors and funding
3 authors.
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Abstract
Apical-basal polarity in epithelial cells is a fundamental process in the morphogenesis of many tissues. But how epithelial cells become oriented with functionally specialized luminal and serosal facing membranes is not understood fully. Cell-cell and cell-substrate contacts induce the asymmetric distribution of Na(+)/K(+)-ATPase pumps on basal membrane and are essential for apical-basal polarity formation. Inhibition of the Na(+)/K(+)-ATPase pump abolished apical formation completely. But it is unclear how this pump regulated the apical polarity. We discovered that the transepithelial potential difference (TEP) which is dependent on the basal Na(+)/K(+)-ATPase distribution acts as an essential coordinating signal for apical membrane formation through Ror2/ERK1/2/LKB1 signaling. A similar concept applies to all other ion-transporting epithelial and endothelial tissues and this raises the possibility of regulating the TEP as a therapeutic intervention for disorders in which epithelial function is compromised by faulty electrical signaling.
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