Evidence map›Paper›PMID 26451300›Full record

ArticleOncoimmunology2015

Interleukin-17A promotes the growth of human germinal center derived non-Hodgkin B cell lymphoma.

Elisa Ferretti, Emma Di Carlo, Emanuela Ognio, Carla Guarnotta, Francesco Bertoni, Anna Corcione, Ignazia Prigione, Giulio Fraternali-Orcioni, Domenico Ribatti, Jean Louis Ravetti and 3 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. The IL-17 family in diseases: from bench to bedside.Signal transduction and targeted therapy · 2023
    Review
  4. Article
  5. TheInternational journal of molecular sciences · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 5 countries.

Elisa FerrettiLaboratorio di Oncologia; Istituto Giannina Gaslini ; Genova, Italia.
Emma Di CarloDepartment of Medicine and Sciences of Aging; "G. d'Annunzio" University and Ce.S.I. Aging Research Center; "G. d'Annunzio" University Foundation ; Chieti, Italy.
Emanuela OgnioIRCCS AOU San Martino-IST-Istituto Nazionale per la Ricerca sul Cancro ; Genova, Italy.
Carla GuarnottaTumor Immunology Unit; Department of Health Science; Human Pathology Section; University of Palermo ; Palermo, Italy.
Francesco BertoniLymphoma & Genomics Research Program; -IOR- Institute of Oncology Research; and -IOSI- Lymphoma Unit; Oncology Institute of Southern Switzerland ; Bellinzona, Switzerland.
Anna CorcioneLaboratorio di Oncologia; Istituto Giannina Gaslini ; Genova, Italia.
Ignazia PrigioneLaboratorio di Oncologia; Istituto Giannina Gaslini ; Genova, Italia.
Giulio Fraternali-OrcioniUnit of Pathology; IRCCS AOU San Martino -IST- Istituto Nazionale per la Ricerca sul Cancro ; Genova, Italy.
Domenico RibattiDepartment of Basic Medical Sciences; Neurosciences and Sensory Organs; University of Bari Medical School ; Bari; Italy ; and National Cancer Institute "Giovanni Paolo II" ; Bari, Italy.
Jean Louis RavettiUnit of Pathology; IRCCS AOU San Martino -IST- Istituto Nazionale per la Ricerca sul Cancro ; Genova, Italy.
Maurilio PonzoniPathology Unit; Unit of Lymphoid Malignancies; San Raffaele Scientific Institute ; Milano, Italy.
Claudio TripodoTumor Immunology Unit; Department of Health Science; Human Pathology Section; University of Palermo ; Palermo, Italy.
Vito PistoiaLaboratorio di Oncologia; Istituto Giannina Gaslini ; Genova, Italia.
Istituto Giannina Gaslini · ITOspedale Policlinico San Martino · ITDepartment of Medical Sciences · BYInstitute of Oncology Research · CHIstituto Nazionale di Fisica Nucleare, Sezione di Milano · ITIstituto Tumori Bari · ITUniversity of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin (IL)-17A belongs to IL-17 superfamily and binds the heterodimeric IL-17 receptor (R)(IL-17RA/IL-17RC). IL-17A promotes germinal center (GC) formation in mouse models of autoimmune or infectious diseases, but the role of IL-17A/IL-17AR complex in human neoplastic GC is unknown. In this study, we investigated expression and function of IL-17A/IL-17AR in the microenvironments of 44 B cell non-Hodgkin lymphomas (B-NHL) of GC origin (15 follicular lymphomas, 17 diffuse large B cells lymphomas and 12 Burkitt lymphomas) and 12 human tonsil GC. Furthermore, we investigated the role of IL-17A in two

Indexed as

angiogenesisB non-Hodgkin lymphomaGC B cellsIL-17AIL-17A receptortumor immunology

Identifiers

PMID26451300
PMCPMC4589990
OpenAlexW1790523863

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.