Evidence map›Paper›PMID 26451293›Full record

ArticleOncoimmunology2015

Progressive loss of anti-HER2 CD4

Jashodeep Datta, Cinthia Rosemblit, Erik Berk, Lori Showalter, Prachi Namjoshi, Rosemarie Mick, Kathreen P Lee, Andrew M Brod, Rachel L Yang, Rachel R Kelz and 7 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
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  16. Beneficial autoimmunity improves cancer prognosis.Nature reviews. Clinical oncology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Jashodeep DattaDepartment of Surgery; University Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
Cinthia RosemblitDepartment of Surgery; University Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
Erik BerkDepartment of Surgery; University Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
Lori ShowalterDepartment of Biological Sciences; Kent State University ; Kent, OH USA.
Prachi NamjoshiDepartment of Biological Sciences; Kent State University ; Kent, OH USA.
Rosemarie MickDepartment of Epidemiology and Biostatistics; University of Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
Kathreen P LeeDepartment of Surgery; University Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
Andrew M BrodDepartment of Surgery; University Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
Rachel L YangDepartment of Surgery; Stanford University Hospital and Clinics ; Palo Alto, CA USA.
Rachel R KelzDepartment of Surgery; University Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
Elizabeth FitzpatrickDepartment of Surgery; University Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
Clifford HoytLife Sciences & Technology; PerkinElmer Inc. ; Hopkinton, MA USA.
Michael D FeldmanDepartment of Pathology; University of Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
Paul J ZhangDepartment of Pathology; University of Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
Shuwen XuDepartment of Surgery; University Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
Gary K KoskiDepartment of Biological Sciences; Kent State University ; Kent, OH USA.
Brian J CzernieckiDepartment of Surgery; University Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA ; Rena Rowen Breast Center; Hospital of the University of Pennsylvania ; Philadelphia, PA USA.
University of Pennsylvania · USKent State University · USHealth & Life (Taiwan) · TWHospital of the University of Pennsylvania · USUniversity Hospital and Clinics · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 1985 to 2026
$222.3M
A HER-2/neu pulsed DC1 vaccine for patients with DCISR01CA096997 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CZERNIECKI, BRIAN JOSEPH · 2003 to 2012
$3.6M
NCI NIH HHS P30 CA016520NCI NIH HHS R01 CA096997
6 · The paper itself

Abstract

Genomic profiling has identified several molecular oncodrivers in breast tumorigenesis. A thorough understanding of endogenous immune responses to these oncodrivers may provide insights into immune interventions for breast cancer (BC). We investigated systemic anti-HER2/

Indexed as

breast cancerCD4+ T-helper immunitydendritic cellHER2/neuimmune monitoringimmune restorationvaccination

Identifiers

PMID26451293
PMCPMC4589053
OpenAlexW1795586350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.