Evidence map›Paper›PMID 26451100›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2015

Budgetary impact analysis on funding smoking-cessation drugs in patients with COPD in Spain.

Carlos A Jiménez-Ruiz, Segismundo Solano-Reina, Jaime Signes-Costa, Eva de Higes-Martinez, José I Granda-Orive, José J Lorza-Blasco, Juan A Riesco-Miranda, Neus Altet-Gomez, Miguel Barrueco, Itziar Oyagüez and 2 more

Abstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carlos A Jiménez-RuizSpecialised Tobacco Unit, Community of Madrid, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Segismundo Solano-ReinaTobacco Unit, Department of Pulmonary Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Jaime Signes-CostaDepartment of Pulmonary Medicine, Hospital Universitario San Juan, Alicante, Madrid, Spain.
Eva de Higes-MartinezDepartment of Pulmonary Medicine, Hospital Universitario Fundación Alcorcón, Madrid, Spain.
José I Granda-OriveDepartment of Pulmonary Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.
José J Lorza-BlascoDepartment of Pulmonary Medicine, Complejo Hospitalario de Navarra, Pamplona, Navarre, Spain.
Juan A Riesco-MirandaDepartment of Pulmonary Medicine, Hospital de San Pedro Alcántara, Cáceres, Spain.
Neus Altet-GomezDrassanes Tobacco Unit, Hospital Universitari Vall-d'Hebron-Drassanes, The Jordi Gol University Institute for Research Primary Healthcare, Barcelona, Spain.
Miguel BarruecoDepartment of Pulmonary Medicine, Hospital Universitario de Salamanca, Biomedical Research Institute, Salamanca, Alcobendas, Madrid, Spain.
Itziar OyagüezPharmacoeconomics & Outcomes Research Iberia, Sociedad Limitada Unificada, Alcobendas, Madrid, Spain.
Javier RejasDepartment of Pharmacoeconomics and Health Outcomes Research, Pfizer, Sociedad Limitada Unificada, Alcobendas, Madrid, Spain.
SESEPARAR’s Integrated Tobacco Research Program

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was to assess the budgetary impact of funding smoking-cessation drugs in COPD patients in Spain. A hybrid model (cohort and Markov) was developed for a 5-year time horizon. Only approved cessation drugs (varenicline, bupropion, and nicotine replacement therapy) were considered. Irrespective of the drug, the model allowed for an initial cessation attempt, and up to three additional attempts in case of failure or smoking relapse during a 5-year period. Drug effectiveness was based on controlled clinical trials. National Health System perspective was applied; therefore, only medical resources were included. The pharmaceutical costs for smoking-cessation drugs, extra medical follow-up as a consequence of public reimbursement, and annual savings for health costs avoided due to stopping smoking were considered. The model estimated that 17,756 COPD patients would stop smoking if public funding was available, compared with 1,303 without reimbursement. In the reimbursement scenario, the savings accounted for a total of €48.0 million, compensating for expenditures on drugs and medical visits (€40.4 million). Accumulated total additional savings in 5 years (€4.3 million) compared with the scenario without reimbursement was shown. Sensitivity analyses supported the results robustness. Funding smoking-cessation drugs in COPD patients seems to be an efficient option and a National Health System drug reimbursement scheme would represent a cost-saving policy in Spain.

Indexed as

AdultAgedAged, 80 and overBupropionCohort StudiesFemaleHealth Care CostsHealth ExpendituresHumansMaleMarkov ChainsMiddle AgedPulmonary Disease, Chronic ObstructiveSmokingSmoking CessationSpainBupropionVareniclinebudgetary impactCOPDhealth servicepharmacotherapysmoking cessation

Identifiers

PMID26451100
PMCPMC4590338

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.