ArticleMediators of inflammation2015
The Role of Cytokines, Chemokines, and Growth Factors in the Pathogenesis of Pityriasis Rosea.
Article in Mediators of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Parvovirus B19 Infection as a Potential Trigger for Systemic Diseases.Clinical case reports · 2025Article
- Purpuric pityriasis rosea in patients with anorexia nervosa.Dermatology reports · 2025Article
- Beyond the Herald Patch: Exploring the Complex Landscape of Pityriasis Rosea.American journal of clinical dermatology · 2025Review
- Herald Patch as the Only Evidence of Pityriasis Rosea: Clinical, Laboratory and Pathogenetic Features.Viruses · 2025Observational
- A retrospective analysis of medications associated with pityriasis rosea reported in the FDA adverse events reporting system.Archives of dermatological research · 2025Article
- Comparative Efficacy of Different Pharmacological Treatments for Pityriasis Rosea: A Network Meta-Analysis.Journal of clinical medicine · 2024Review
- Coronavirus disease 2019 and pityriasis rosea: A review of the immunological connection.The Journal of dermatology · 2022Review
- The significance of investigating clinical, histopathologic and virological features in pityriasis rosea and pityriasis rosea-like eruptions following COVID-19 vaccinations.Dermatologic therapy · 2022Article
- Pityriasis rosea during COVID-19: Pathogenesis, diagnosis, and treatment.Journal of medical virology · 2022Article
- Thiol-Disulfide Homeostasis in Skin Diseases.Journal of clinical medicine · 2022Review
- Expression Patterns of Macrophage Migration Inhibitory Factor and Its Gene Variants (MIF-173 G˃C) in Verruca Vulgaris.Clinical, cosmetic and investigational dermatology · 2022Article
- Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance.Journal of the European Academy of Dermatology and Venereology : JEADV · 2021Article
- Evidence of "Silent" Hepatitis B Virus Infection in Psoriasis, Vitiligo, andIndian journal of dermatologyArticle
- Pityriasis rosea, pityriasis rosea-like eruptions, and herpes zoster in the setting of COVID-19 and COVID-19 vaccination.Clinics in dermatologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPityriasis rosea (PR) is an exanthematous disease related to human herpesvirus- (HHV-) 6/7 reactivation. The network of mediators involved in recruiting the infiltrating inflammatory cells has never been studied. Object. To investigate the levels of serum cytokines, growth factors, and chemokines in PR and healthy controls in order to elucidate the PR pathogenesis. MATERIALS AND
methodsInterleukin- (IL-) 1, IL-6, IL-17, interferon- (IFN-) γ, tumor necrosis factor- (TNF-) α, vascular endothelial growth factor (VEGF), granulocyte colony stimulating factor (G-CSF), and chemokines, CXCL8 (IL-8) and CXCL10 (IP-10), were measured simultaneously by a multiplex assay in early acute PR patients' sera and healthy controls. Subsequently, sera from PR patients were analysed at 3 different times (0, 15, and 30 days). RESULTS AND DISCUSSION: Serum levels of IL-17, IFN-γ, VEGF, and IP-10 resulted to be upregulated in PR patients compared to controls. IL-17 has a key role in host defense against pathogens stimulating the release of proinflammatory cytokines/chemokines. IFN-γ has a direct antiviral activity promoting NK cells and virus specific T cells cytotoxicity. VEGF stimulates vasculogenesis and angiogenesis. IP-10 can induce chemotaxis, apoptosis, cell growth, and angiogenesis.
conclusionsOur findings suggest that these inflammatory mediators may modulate PR pathogenesis in synergistic manner.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.