Evidence map›Paper›PMID 26451070›Full record

Trial reportDisease markers2015

High-Dose versus Low-Dose Vitamin D Supplementation and Arterial Stiffness among Individuals with Prehypertension and Vitamin D Deficiency.

Amanda Zaleski, Gregory Panza, Heather Swales, Pankaj Arora, Christopher Newton-Cheh, Thomas Wang, Paul D Thompson, Beth Taylor

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Disease markers, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01240512 (Daylight), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01240512 nacompletednot on this map

Daylight: The Effect of Vitamin D Supplementation on Blood Pressure in Vitamin D Deficient Individuals With Pre-Hypertension

TypeinterventionalSponsorMassachusetts General HospitalRan2010 to 2013Enrolled534ConditionsHypertension, Vitamin D Deficiency, Pre-HypertensionArmsCholecalciferol
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Amanda ZaleskiDivision of Cardiology, Hartford Hospital, Hartford, CT 06102, USA ; Department of Kinesiology, University of Connecticut, Storrs, CT 06069, USA.
Gregory PanzaDivision of Cardiology, Hartford Hospital, Hartford, CT 06102, USA ; Department of Kinesiology, University of Connecticut, Storrs, CT 06069, USA.
Heather SwalesDivision of Cardiology, Hartford Hospital, Hartford, CT 06102, USA.
Pankaj AroraCardiology Division, Department of Medicine, University of Alabama, Birmingham, AL 16686, USA.
Christopher Newton-ChehCardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.
Thomas WangDivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37201, USA.
Paul D ThompsonDivision of Cardiology, Hartford Hospital, Hartford, CT 06102, USA.
Beth TaylorDivision of Cardiology, Hartford Hospital, Hartford, CT 06102, USA ; Department of Kinesiology, University of Connecticut, Storrs, CT 06069, USA.
Hartford Hospital · USHarvard University · USUniversity of Alabama at Birmingham · USVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionVitamin D deficiency is associated with the onset and progression of hypertension and cardiovascular disease (CVD). However, mechanisms underlying vitamin D deficiency-mediated increased risk of CVD remain unknown. We sought to examine the differential effect of high-dose versus low-dose vitamin D supplementation on markers of arterial stiffness among ~40 vitamin D deficient adults with prehypertension.

methodsParticipants were randomized to high-dose (4000 IU/d) versus low-dose (400 IU/d) oral vitamin D3 for 6 months. 24 hr ambulatory blood pressure (BP), carotid-femoral pulse wave velocity, and pulse wave analyses were obtained at baseline and after 6 months of vitamin D supplementation.

resultsThere were no changes in resting BP or pulse wave velocity over 6 mo regardless of vitamin D dose (all p > 0.202). High-dose vitamin D decreased augmentation index and pressure by 12.3 ± 5.3% (p = 0.047) and 4.0 ± 1.5 mmHg (p = 0.02), respectively. However, these decreases in arterial stiffness were not associated with increases in serum 25-hydroxyvitamin D over 6 mo (p = 0.425).

conclusionHigh-dose vitamin D supplementation appears to lower surrogate measures of arterial stiffness but not indices of central pulse wave velocity. Clinical Trial Registration. This trial is registered with www.clinicaltrials.gov (Unique Identifier: NCT01240512).

Indexed as

Vascular StiffnessAdultBlood PressureFemaleHumansMaleMiddle AgedPrehypertensionPulse Wave AnalysisVitamin DVitamin D DeficiencyVitaminsVitamin DVitamins

Identifiers

PMID26451070
PMCPMC4588343
OpenAlexW1901953630

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.