Evidence map›Paper›PMID 26450848›Full record

ArticleNeurocritical care2016

Preventive Antibiotics and Delayed Cerebral Ischaemia in Patients with Aneurysmal Subarachnoid Haemorrhage Admitted to the Intensive Care Unit.

Celine S Gathier, Evelien A Oostdijk, Gabriel J E Rinkel, Sanne M Dorhout Mees, Mervyn D I Vergouwen, Anne Marie G A de Smet, Diederik van de Beek, W Peter Vandertop, Dagmar Verbaan, Ale Algra and 2 more

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In one paragraph

Article in Neurocritical care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Celine S GathierDepartment of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands. c.s.gathier-2@umcutrecht.nl.
Evelien A OostdijkDepartment of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Gabriel J E RinkelDepartment of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Room F.06.134, PO Box 85500, 3508 GA, Utrecht, The Netherlands.
Sanne M Dorhout MeesDepartment of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Room F.06.134, PO Box 85500, 3508 GA, Utrecht, The Netherlands.
Mervyn D I VergouwenDepartment of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Room F.06.134, PO Box 85500, 3508 GA, Utrecht, The Netherlands.
Anne Marie G A de SmetDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Diederik van de BeekDepartment of Neurology, Center of Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands.
W Peter VandertopDepartment of Neurosurgery, Neurosurgical Center Amsterdam, Academic Medical Center, Amsterdam, The Netherlands.
Dagmar VerbaanDepartment of Neurosurgery, Neurosurgical Center Amsterdam, Academic Medical Center, Amsterdam, The Netherlands.
Ale AlgraDepartment of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Room F.06.134, PO Box 85500, 3508 GA, Utrecht, The Netherlands.
Marc J M BontenDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Walter M van den BerghDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
University Medical Center Utrecht · NLAcademic Medical Center · NLUniversity Medical Center Groningen · NLUniversity of Groningen · NL

Funding

European Research Council 281156
6 · The paper itself

Abstract

introductionDelayed cerebral ischemia (DCI) is an important contributor to poor outcome after aneurysmal subarachnoid haemorrhage (aSAH). Development of DCI is multifactorial, and inflammation, with or without infection, is one of the factors independently associated with development of DCI and poor outcome. We thus postulated that preventive antibiotics might be associated with a reduced risk of DCI and subsequent poor outcome in aSAH patients.

methodsWe performed a retrospective cohort-study in intensive care units (ICU) of three university hospitals in The Netherlands. We included consecutive aSAH patients with minimal ICU stay of 72 h who received either preventive antibiotics (SDD: selective digestive tract decontamination including systemic cefotaxime or SOD: selective oropharyngeal decontamination) or no preventive antibiotics. DCI was defined as a new hypodensity on CT with no other explanation than DCI. Hazard ratio's (HR) for DCI and risk ratio's (RR) for 28-day case-fatality and poor outcome at 3 months were calculated, with adjustment (aHR/aRR) for clinical condition on admission, recurrent bleeding, aneurysm treatment modality and treatment site.

resultsOf 459 included patients, 274 received preventive antibiotics (SOD or SDD) and 185 did not. With preventive antibiotics, the aHR for DCI was 1.0 (95% CI 0.6-1.8), the aRR for 28-day case-fatality was 1.1 (95% CI 0.7-1.9) and the aRR for poor functional outcome 1.2 (95% CI 1.0-1.4).

conclusionsPreventive antibiotics were not associated with reduced risk of DCI or poor outcome in aSAH patients in the ICU.

Indexed as

Outcome Assessment, Health CareAdultAgedAged, 80 and overAnti-Bacterial AgentsBrain IschemiaCase-Control StudiesFemaleHumansIntensive Care UnitsIntracranial AneurysmMaleMiddle AgedRetrospective StudiesSubarachnoid HemorrhageYoung AdultAnti-Bacterial AgentsAneurysmal subarachnoid haemorrhageAntibioticsCase–control studyDelayed cerebral ischaemiaIntensive care unit

Identifiers

PMID26450848
OpenAlexW1914657809

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.