ArticlePhysiological measurement2015
In vitro validation of endovascular Doppler-derived flow rates in models of the cerebral circulation.
Article in Physiological measurement, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Sonographic Extracranial-Intracranial Bypass Monitoring: Technical Evolution and Current Evidence.Brain sciences · 2026Review
- Endothelial Cell Transcription Modulation in Cerebral Aneurysms After Endovascular Flow Diversion.Annals of biomedical engineering · 2024Article
- Validation of ultrasound velocimetry and computational fluid dynamics for flow assessment in femoral artery stenotic disease.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Standardized viscosity as a source of error in computational fluid dynamic simulations of cerebral aneurysms.Medical physics · 2024Article
- Improving the accuracy of computational fluid dynamics simulations of coiled cerebral aneurysms using finite element modeling.Journal of biomechanics · 2023Article
- Computational Fluid Dynamics for the Prediction of Endograft Thrombosis in the Superficial Femoral Artery.Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists · 2023Article
- Reconstructing patient-specific cerebral aneurysm vasculature for in vitro investigations and treatment efficacy assessments.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2019Article
- Article
- Computational fluid dynamics of cerebral aneurysm coiling using high-resolution and high-energy synchrotron X-ray microtomography: comparison with the homogeneous porous medium approach.Journal of neurointerventional surgery · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
This study presents validation of endovascular Doppler velocimetry-based volumetric flow rate measurements conducted in a pulsatile flow loop simulating conditions in both the internal carotid and basilar artery. In vitro models of cerebral vessels, each containing an aneurysm, were fabricated from patient anatomies extracted from 3D rotational angiography. Flow velocity measurements were collected with three different experimental techniques: an endovascular Doppler wire, Particle Image Velocimetry, and a time-resolved ultrasonic flow meter. Womersley's theory of pulsatile flow in a cylindrical vessel was used to compute time-resolved volumetric flow rates from the endovascular Doppler velocity. The volumetric flow rates computed from the Doppler measurements were compared to those from the Particle Image Velocimetry profile measurements, and the direct measurements from the ultrasonic flow meter. The study establishes confidence intervals for any systematic or random errors associated with the wire-derived flow rates as benchmarked to the other two modalities. There is an approximately 10% random error in the Doppler-derived peak and time-averaged flow rates. There is a measurable uniform bias, about 15% too low, in the time-averaged Doppler-derived flow rates. There is also a small proportional bias in the peak systolic Doppler-derived flow rates. Potential sources of error are also discussed.
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Registered trials
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