Evidence map›Paper›PMID 26450601›Full record

Trial reportEuropean journal of nutrition2017

A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive women.

C E Storniolo, R Casillas, M Bulló, O Castañer, E Ros, G T Sáez, E Toledo, R Estruch, V Ruiz-Gutiérrez, M Fitó and 4 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04025281 (Post-prandial Effects of Extra Virgin Olive Oil on Endothelial Function in Adults at Risk for Type 2 Diabetes), which is not on this map. Cited by 58 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 5 pooled it
10.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04025281 nacompletednot on this mapstarted 2019, after this paper: background citation

Post-prandial Effects of Extra Virgin Olive Oil on Endothelial Function in Adults at Risk for Type 2 Diabetes: A Randomized Crossover Controlled Trial

TypeinterventionalSponsorGriffin HospitalRan2019 to 2019Enrolled20ConditionsType 2 DiabetesArmsExtra Virgin Olive Oil, Refined Olive Oil
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 5 syntheses or guidelines pooled it, 120 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. A comprehensive review ofRSC advances · 2026
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Extra Virgin Olive Oil and Metabolic Diseases.International journal of molecular sciences · 2024
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

C E StornioloDepartment of Physiology, University of Barcelona, Barcelona, Spain.
R CasillasDepartment of Physiology, University of Barcelona, Barcelona, Spain.
M BullóHuman Nutrition Unit, HSPV, Rovira i Virgili University, Reus, Spain.
O CastañerCardiovascular Risk and Nutrition Research Group, IMIM-Institut de Recerca Hospital del Mar, Barcelona, Spain.
E RosEndocrinology and Nutrition Service, Hospital Clinic, Barcelona, Spain.
G T SáezDepartment of Biochemistry and Molecular Biology, Clinical Analysis Service-CDB HGUV, University of Valencia, Valencia, Spain.
E ToledoDepartment of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
R EstruchDepartment of Internal Medicine, University of Barcelona, Barcelona, Spain.
V Ruiz-GutiérrezInstituto de la Grasa, Consejo Superior de Investigaciones Científicas, Seville, Spain.
M FitóCardiovascular Risk and Nutrition Research Group, IMIM-Institut de Recerca Hospital del Mar, Barcelona, Spain.
M A Martínez-GonzálezDepartment of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
J Salas-SalvadóHuman Nutrition Unit, HSPV, Rovira i Virgili University, Reus, Spain.
M T MitjavilaDepartment of Physiology, University of Barcelona, Barcelona, Spain.
J J MorenoDepartment of Physiology, University of Barcelona, Barcelona, Spain. jjmoreno@ub.edu.
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition · ESUniversitat de Barcelona · ESUniversidad de Navarra · ESInstituto de la Grasa · ESInstituto de Salud Carlos III · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSerum nitric oxide (NO) reduction and increased endothelin-1 (ET-1) play a pivotal role in endothelial dysfunction and hypertension. Considering that traditional Mediterranean diet (TMD) reduces blood pressure (BP), the aim of this study was to analyze whether TMD induced changes on endothelial physiology elements such as NO, ET-1 and ET-1 receptors which are involved in BP control.

methodsNon-smoking women with moderate hypertension were submitted for 1 year to interventions promoting adherence to the TMD, one supplemented with extra virgin olive oil (EVOO) and the other with nuts versus a control low-fat diet (30 participants/group). BP, NO, ET-1 and related gene expression as well as oxidative stress biomarkers were measured.

resultsSerum NO and systolic BP (SBP) or diastolic BP (DBP) were negatively associated at baseline, as well as between NO and ET-1. Our findings also showed a DBP reduction with both interventions. A negative correlation was observed between changes in NO metabolites concentration and SBP or DBP after the intervention with TMD + EVOO (p = 0.033 and p = 0.044, respectively). SBP reduction was related to an impairment of serum ET-1 concentrations after the intervention with TMD + nuts (p = 0.008). We also observed changes in eNOS, caveolin 2 and ET-1 receptors gene expression which are related to NO metabolites levels and BP.

conclusionsThe changes in NO and ET-1 as well as ET-1 receptors gene expression explain, at least partially, the effect of EVOO or nuts on lowering BP among hypertensive women.

Indexed as

Blood PressureDiet, MediterraneanNutsAgedAged, 80 and overBiomarkersBlood GlucoseBody Mass IndexBody WeightCholesterol, HDLCholesterol, LDLDiet, Fat-RestrictedEndothelin-1FemaleGene Expression RegulationHumansBiomarkersBlood GlucoseCholesterol, HDLCholesterol, LDLEndothelin-1Nitric OxideOlive OilReceptor, Endothelin ATriglyceridesEndothelin-1HypertensionNitric oxideOxidative stressPREDIMED study

Identifiers

PMID26450601
OpenAlexW1828517885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.