Evidence map›Paper›PMID 26450575›Full record

ArticleEMBO reports2015

No time to waste--the ethical challenges created by CRISPR: CRISPR/Cas, being an efficient, simple, and cheap technology to edit the genome of any organism, raises many ethical and regulatory issues beyond the use to manipulate human germ line cells.

Arthur L Caplan, Brendan Parent, Michael Shen, Carolyn Plunkett

Abstract read
In one paragraph

Article in EMBO reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. The ethics of genome editing in non-human animals: a systematic review of reasons reported in the academic literature.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
    Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Article
  7. Review
  8. CRISPR-Cas9 in the Tailoring of Genetically Engineered Animals.Current issues in molecular biology · 2025
    Review
  9. Review
  10. Review
  11. Review
  12. Advancements in genetic studies of mushrooms: a comprehensive review.World journal of microbiology & biotechnology · 2024
    Review
  13. Article
  14. Review
  15. LbCas12a mediated suppression ofFrontiers in plant science · 2023
    Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Arthur L CaplanDivision of Medical Ethics, New York University Langone Medical Center, New York, NY, USA.
Brendan ParentDivision of Medical Ethics, New York University Langone Medical Center, New York, NY, USA.
Michael ShenInstitute for Systems Genetics, New York University Langone Medical Center, New York, NY, USA.
Carolyn PlunkettDivision of Medical Ethics, New York University Langone Medical Center, New York, NY, USA Philosophy Department, The Graduate Center CUNY, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CRISPR-Cas SystemsEthics, ResearchGerm CellsOrganisms, Genetically ModifiedAnimalsGenetic EngineeringGenomeHumans

Identifiers

PMID26450575
PMCPMC4641494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.