ArticlePublic health nutrition2016
The association between soya consumption and serum thyroid-stimulating hormone concentrations in the Adventist Health Study-2.
Article in Public health nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Thyroid function and urinary concentrations of iodine, selenium, and arsenic in vegans, lacto-ovo vegetarians and pescatarians.European journal of nutrition · 2023Article
- The health effects of soy: A reference guide for health professionals.Frontiers in nutrition · 2022Review
- Skeletal Effects of Early-Life Exposure to Soy Isoflavones-A Review of Evidence From Rodent Models.Frontiers in pediatrics · 2020Review
- Soy, Soy Foods and Their Role in Vegetarian Diets.Nutrients · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveConsumers may choose soya foods as healthful alternatives to animal products, but concern has arisen that eating large amounts of soya may adversely affect thyroid function. The present study aimed to examine the association between soya food consumption and serum thyroid-stimulating hormone (TSH) concentrations in North American churchgoers belonging to the Seventh-day Adventist denomination that encourages vegetarianism.
designParticipants completed six repeated 24 h dietary recalls within a 6-month period. Soya protein and soya isoflavone intakes were estimated, and their relationships to TSH concentrations measured at the end of 6 months were calculated using logistic regression analyses.
settingCalibration sub-study of the Adventist Health Study-2. SUBJECTS: Women (n 548) and men (n 295) who were not taking thyroid medications.
resultsIn men, age and urinary iodine concentrations were associated with high serum TSH concentrations (>5 mIU/l), while among women White ethnicity was associated with high TSH. In multivariate models adjusted for age, ethnicity and urinary iodine, soya isoflavone and protein intakes were not associated with high TSH in men. In women higher soya isoflavone consumption was associated with higher TSH, with an adjusted odds ratio (highest v. lowest quintile) of 4·17 (95 % CI 1·73, 10·06). Likewise, women with high consumption of soya protein (midpoint of highest quintile, 11 g/d) v. low consumption (midpoint of lowest quintile, 0 g/d) carried increased odds of high TSH (OR=2·69; 95 % CI 1·34, 5·30).
conclusionsIn women high consumption of soya was associated with elevated TSH concentrations. No associations between soya intake and TSH were found in men.
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