ArticleNature communications2015
Hyperpolarized nanodiamond with long spin-relaxation times.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Comparing low-field cryogenic nuclear relaxation of hyperpolarized diamond and silicon particles.Scientific reports · 2025Article
- Temperature-Dependent Dynamic Nuclear Polarization of Diamond.The journal of physical chemistry. C, Nanomaterials and interfaces · 2025Article
- Achieving 5%Scientific reports · 2025Article
- Modelling and correcting the impact of RF pulses for continuous monitoring of hyperpolarized NMR.Magnetic resonance (Gottingen, Germany) · 2023Article
- Preclinical PET and MR Evaluation ofNanomaterials (Basel, Switzerland) · 2022Article
- Large Room Temperature Bulk DNP ofThe journal of physical chemistry. C, Nanomaterials and interfaces · 2022Article
- High field magnetometry with hyperpolarized nuclear spins.Nature communications · 2022Article
- Optical Dynamic Nuclear Polarization ofMolecules (Basel, Switzerland) · 2022Article
- Optimal metrology with programmable quantum sensors.Nature · 2022Article
- Dynamic Nuclear Polarization of Silicon Carbide Micro- and Nanoparticles.ACS applied materials & interfaces · 2021Article
- Hyperpolarized relaxometry based nuclear TNature communications · 2019Article
- A Perspective on Fluorescent Nanodiamond Bioimaging.Small (Weinheim an der Bergstrasse, Germany) · 2019Review
- Carbon-13 dynamic nuclear polarization in diamond via a microwave-free integrated cross effect.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Review Article: Synthesis, properties, and applications of fluorescent diamond particles.Journal of vacuum science and technology. B, Nanotechnology & microelectronics : materials, processing, measurement, & phenomena : JVST B · 2019Review
- Phase-Encoded Hyperpolarized Nanodiamond for Magnetic Resonance Imaging.Scientific reports · 2019Article
- Nitrogen-vacancy centers in diamond for nanoscale magnetic resonance imaging applications.Beilstein journal of nanotechnology · 2019Review
- Robust optical polarization of nuclear spin baths using Hamiltonian engineering of nitrogen-vacancy center quantum dynamics.Science advances · 2018Article
- Orientation-independent room temperature opticalScience advances · 2018Article
- Quantum probe hyperpolarisation of molecular nuclear spins.Nature communications · 2018Article
- Nanodiamond-enhanced MRI via in situ hyperpolarization.Nature communications · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of hyperpolarized agents in magnetic resonance, such as (13)C-labelled compounds, enables powerful new imaging and detection modalities that stem from a 10,000-fold boost in signal. A major challenge for the future of the hyperpolarization technique is the inherently short spin-relaxation times, typically <60 s for (13)C liquid-state compounds, which limit the time that the signal remains boosted. Here we demonstrate that 1.1% natural abundance (13)C spins in synthetic nanodiamond can be hyperpolarized at cryogenic and room temperature without the use of free radicals, and, owing to their solid-state environment, exhibit relaxation times exceeding 1 h. Combined with the already established applications of nanodiamonds in the life sciences as inexpensive fluorescent markers and non-cytotoxic substrates for gene and drug delivery, these results extend the theranostic capabilities of nanoscale diamonds into the domain of hyperpolarized magnetic resonance.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.