ArticleBMC neurology2015
Coma recovery scale-r: variability in the disorder of consciousness.
Article in BMC neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- EEG-based Brain-Computer Interfaces for people with Disorders of Consciousness: Features and applications. A systematic review.Frontiers in human neuroscience · 2022Pooled it
- Guideline
- The autonomic response following taVNS predicts changes in level of consciousness in DoC patients.Scientific reports · 2025Trial
- Transcranial direct current stimulation enhances cognitive performance and modulates QEEG beta- and theta-band power in patients undergoing whole-brain radiotherapy.IBRO neuroscience reports · 2026Article
- Temporal Interference Stimulation of Centromedian-Parafascicular Complex in Disorders of Consciousness: A Pilot Study.Annals of clinical and translational neurology · 2026Article
- Prospective validation protocol for artificial intelligence-assisted standardization of Coma Recovery Scale-Revised scores using electroencephalography and clinical data in disorders of consciousness.Frontiers in medicine · 2026Article
- Short-term changes in CRS-R scores during transcutaneous auricular vagus nerve stimulation in prolonged disorders of consciousness: a single-arm exploratory study.Frontiers in neurology · 2026Article
- From detection to decision: a conceptual framework of uncertainty migration in disorders of consciousness.Frontiers in neurology · 2026Review
- Behavioral Fluctuation in Disorders of Consciousness: A Retrospective Analysis.Archives of physical medicine and rehabilitation · 2025Observational
- Cortical signatures linked to behavior quantitatively track arousal levels.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Do individuals with disorders of consciousness dream and mind wander? Implications for improving diagnosis and understanding patient wellbeing.Neuroscience of consciousness · 2025Article
- Discriminative power of diverse nonlinear EEG dynamics across consciousness states during auditory stimulation in disorders of consciousness.Frontiers in human neuroscience · 2025Article
- Prognostic Evaluation of Disorders of Consciousness by Using Resting-State fMRI: A Systematic Review.Journal of clinical medicine · 2024Review
- The Constrained Disorder Principle May Account for Consciousness.Brain sciences · 2024Review
- Modelling developments in consciousness within a multidimensional framework.Neuroscience of consciousness · 2024Article
- Variability of large timescale functional networks in patients with disorders of consciousness.Frontiers in neurology · 2024Article
- Wessex Head Injury Matrix in Patients with Prolonged Disorders of Consciousness: A Reliability Study.Biomedicines · 2023Article
- Feasibility and Validity of the Coma Recovery Scale-Revised for Accelerated Standardized Testing: A Practical Assessment Tool for Detecting Consciousness in the Intensive Care Unit.Annals of neurology · 2023Article
- Behavioral scales variability in patients with prolonged disorders of consciousness.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Prognostication, Ethical Issues, and Palliative Care in Disorders of Consciousness.Neurologic clinics · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite evidence from neuroimaging research, diagnosis and early prognosis in the vegetative (VS/UWS) and minimally conscious (MCS) states still depend on the observation of clinical signs of responsiveness. Multiple testing has documented a systematic variability during the day in the incidence of established signs of responsiveness. Spontaneous fluctuations of the Coma Recovery Scale-revised (CRS-r) scores are conceivable.
methodsWe retrospectively analyzed the CRS-r repeatedly administered to 7 VS/UWS and 12 MCS subjects undergoing systematic observation during a conventional 13 weeks. rehabilitation plan.
resultsThe CRS-r global, visual and auditory scores were found higher in the morning than at the afternoon administration in both VS/UWS and MCS subgroups over the entire period of observation. The probability for a VS/UWS subject of being classified as MCS at the morning testing at least once during the 13 weeks. observation was as high as 30%, i.e., compatible with the reported misdiagnosis rate between the two clinical conditions.
conclusionsMultiple CRS-r testing is advisable to minimize the risk of misclassification; estimates of spontaneous variability could be used to characterize with greater accuracy patients with disorder of consciousness and possibly help optimize the rehabilitation plan.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.