ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015
Salmonella Bacteremia Among Children in Central and Northwest Nigeria, 2008-2015.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 48 citations in OpenAlex.
- Prevalence, antimicrobial resistance, and genomic characterization of Salmonella strains isolated in Hangzhou, China: a two-year study.Annals of clinical microbiology and antimicrobials · 2024Article
- Oral Antibiotics for Bacteremia and Infective Endocarditis: Current Evidence and Future Perspectives.Microorganisms · 2023Review
- Molecular characterization ofMicrobial genomics · 2023Article
- Whole genome sequencing of Salmonella enterica serovars isolated from humans, animals, and the environment in Lagos, Nigeria.BMC microbiology · 2023Article
- Co-existence of extended-spectrum β-lactamases blaEuropean journal of medical research · 2023Article
- Antimicrobial resistance and virulence genes of invasiveSAGE open medicine · 2023Article
- Genomic characterization of invasive typhoidal and non-typhoidal Salmonella in southwestern Nigeria.PLoS neglected tropical diseases · 2022Article
- Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now?Infection and drug resistance · 2022Review
- Antimicrobial Resistance in Endemic Enteric Infections in Kenya and the Region, and Efforts Toward Addressing the Challenges.The Journal of infectious diseases · 2021Article
- Multi-drug resistance and high mortality associated with community-acquired bloodstream infections in children in conflict-affected northwest Nigeria.Scientific reports · 2021Article
- The genomic epidemiology of multi-drug resistant invasive non-typhoidalBMJ global health · 2021Article
- A Prospective Cohort Study of the Clinical Predictors of Bacteremia in Under-Five Children With Acute Undifferentiated Fever Attending a Secondary Health Facility in Northwestern Nigeria.Frontiers in pediatrics · 2021Article
- High relatedness of invasive multi-drug resistant non-typhoidal Salmonella genotypes among patients and asymptomatic carriers in endemic informal settlements in Kenya.PLoS neglected tropical diseases · 2020Article
- Emerging and re-emerging bacterial zoonoses in Nigeria: current preventive measures and future approaches to intervention.Heliyon · 2020Review
- Bacteremia Caused by Salmonella Poona in a Healthy Adult in Tokyo, Japan.Internal medicine (Tokyo, Japan) · 2020Article
- Molecular characterization of invasive Enterobacteriaceae from pediatric patients in Central and Northwestern Nigeria.PloS one · 2020Article
- Risk Factors for NontyphiThe American journal of tropical medicine and hygiene · 2020Article
- Bacteremia Among Febrile Patients Attending Selected Healthcare Facilities in Ibadan, Nigeria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Emergence of New Delhi Metallo-β-Lactamase (NDM-5) inmSphere · 2019Article
- Multidrug-resistant Nontyphoidal Salmonella Hotspots as Targets for Vaccine Use in Management of Infections in Endemic Settings.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
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Authors and funding
31 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundEtiologic agents of childhood bacteremia remain poorly defined in Nigeria. The absence of such data promotes indiscriminate use of antibiotics and delays implementation of appropriate preventive strategies.
methodsWe established diagnostic laboratories for bacteremia surveillance at regional sites in central and northwest Nigeria. Acutely ill children aged <5 years with clinically suspected bacteremia were evaluated at rural and urban clinical facilities in the Federal Capital Territory, central region and in Kano, northwest Nigeria. Blood was cultured using the automated Bactec incubator system.
resultsBetween September 2008 and April 2015, we screened 10,133 children. Clinically significant bacteremia was detected in 609 of 4051 (15%) in the northwest and 457 of 6082 (7.5%) in the central region. Across both regions, Salmonella species account for 24%-59.8% of bacteremias and are the commonest cause of childhood bacteremia, with a predominance of Salmonella enterica serovar Typhi. The prevalence of resistance to ampicillin, chloramphenicol, and cotrimoxazole was 38.11%, with regional differences in susceptibility to different antibiotics but high prevalence of resistance to readily available oral antibiotics.
conclusionsSalmonella Typhi is the leading cause of childhood bacteremia in central Nigeria. Expanded surveillance is planned to define the dynamics of transmission. The high prevalence of multidrug-resistant strains calls for improvement in environmental sanitation in the long term and vaccination in the short term.
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