Evidence map›Paper›PMID 26449884›Full record

Trial reportAcupuncture in medicine : journal of the British Medical Acupuncture Society2015

Effect of 100 Hz electroacupuncture on salivary immunoglobulin A and the autonomic nervous system.

Waki Hideaki, Hisajima Tatsuya, Miyazaki Shogo, Yoshida Naruto, Tamai Hideaki, Minakawa Yoichi, Okuma Yoshihiro, Uebaba Kazuo, Takahashi Hidenori

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acupuncture in medicine : journal of the British Medical Acupuncture Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05437874 (Effects of Carbonated Beverage Consumption on Oral pH and Bacterial Proliferation in Adolescents), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05437874 phase1completednot on this mapstarted 2018, after this paper: background citation

Effects of Carbonated Beverage Consumption on Oral pH and Bacterial Proliferation in Adolescents: A Randomized Crossover Clinical Trial.

TypeinterventionalSponsorHospital Infantil de Mexico Federico GomezRan2018 to 2019Enrolled18ConditionspH, Saliva, Dental PlaqueArmsNatural Water
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Waki HideakiGraduate School of Health Sciences, Teikyo Heisei University, Tokyo, Japan.
Hisajima TatsuyaFaculty of Health Care, Teikyo Heisei University, Tokyo, Japan Research Institute of Oriental Medicine, Teikyo Heisei University, Tokyo, Japan.
Miyazaki ShogoFaculty of Health Care, Teikyo Heisei University, Tokyo, Japan Research Institute of Oriental Medicine, Teikyo Heisei University, Tokyo, Japan.
Yoshida NarutoFaculty of Health Care, Teikyo Heisei University, Tokyo, Japan Research Institute of Oriental Medicine, Teikyo Heisei University, Tokyo, Japan.
Tamai HideakiFaculty of Health Care, Teikyo Heisei University, Tokyo, Japan Research Institute of Oriental Medicine, Teikyo Heisei University, Tokyo, Japan.
Minakawa YoichiFaculty of Health Care, Teikyo Heisei University, Tokyo, Japan Research Institute of Oriental Medicine, Teikyo Heisei University, Tokyo, Japan.
Okuma YoshihiroFaculty of Health Care, Teikyo Heisei University, Tokyo, Japan Research Institute of Oriental Medicine, Teikyo Heisei University, Tokyo, Japan.
Uebaba KazuoFaculty of Health Care, Teikyo Heisei University, Tokyo, Japan Research Institute of Oriental Medicine, Teikyo Heisei University, Tokyo, Japan.
Takahashi HidenoriFaculty of Health Care, Teikyo Heisei University, Tokyo, Japan Research Institute of Oriental Medicine, Teikyo Heisei University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA previous study has reported that low-frequency (LF) electroacupuncture (EA) influences salivary secretory immunoglobulin A (sIgA) and the autonomic nervous system (ANS). The ANS is known to control the secretion volume of sIgA; however, the effect of high-frequency (HF) EA on salivary sIgA has not been determined. We investigated whether HF EA affects salivary sIgA levels and the ANS.

methodSixteen healthy subjects were randomly classified into two groups: a control group and an EA group. After a 5 min rest, subjects in the EA group received EA at 100 Hz bilaterally at LI4 and LI11 for 15 min before resting for a further 40 min post-stimulation. Subjects in the control group rested for a total of 60 min. Measurements of the ANS and sIgA levels in both groups were made before, immediately after, 20 min after, and 40 min after rest or 15 min EA treatment. HF and LF components of heart rate variability were analysed as markers of ANS function. LF/HF ratio and HF were taken as indices of sympathetic and parasympathetic nerve activity, respectively. Salivary protein concentrations and sIgA levels were determined by Bradford protein assay and ELISA, respectively.

resultsLF/HF ratio was significantly increased immediately after EA. HF was significantly increased at 20 min after EA and sIgA level was significantly increased at 40 min after EA. In addition, HF and salivary sIgA level were positively correlated with each another.

conclusionsHF EA exerted sequential positive effects on sympathetic nerve activity, parasympathetic nerve activity, and salivary sIgA level (immediately and after 20 and 40 min, respectively). HF EA may increase salivary sIgA levels by influencing parasympathetic nerve activity.

Indexed as

Autonomic Nervous SystemElectroacupunctureAcupuncture PointsAdultAgedAged, 80 and overHeart RateHumansImmunoglobulin A, SecretoryMiddle AgedSalivaSalivary Proteins and PeptidesYoung AdultImmunoglobulin A, SecretorySalivary Proteins and Peptides

Identifiers

PMID26449884
PMCPMC4860969

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.