ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015
Long-term Consistency in Rotavirus Vaccine Protection: RV5 and RV1 Vaccine Effectiveness in US Children, 2012-2013.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Community-level interventions for mitigating the risk of waterborne diarrheal diseases: a systematic review.Systematic reviews · 2022Pooled it
- Do Rotavirus Strains Affect Vaccine Effectiveness? A Systematic Review and Meta-analysis.The Pediatric infectious disease journal · 2021Pooled it
- Real-world effectiveness of rotavirus vaccines, 2006-19: a literature review and meta-analysis.The Lancet. Global health · 2020Pooled it
- The Use of Test-negative Controls to Monitor Vaccine Effectiveness: A Systematic Review of Methodology.Epidemiology (Cambridge, Mass.) · 2020Pooled it
- Rotavirus shedding following administration of RV3-BB human neonatal rotavirus vaccine.Human vaccines & immunotherapeutics · 2017Trial
- Effectiveness of a live oral human rotavirus vaccine after programmatic introduction in Bangladesh: A cluster-randomized trial.PLoS medicine · 2017Trial
- Effectiveness of the oral rotavirus vaccine ROTASIIL among children hospitalized with acute gastroenteritis in India.Nature communications · 2026Observational
- Epidemiology and Clinical Impact of Pediatric Viral Gastroenteritis Before and After Rotavirus Vaccination in Sicily.Pathogens (Basel, Switzerland) · 2026Article
- Prevalence of group A rotavirus G and P genotypes in children with acute gastroenteritis in China from 2020 to 2021.Archives of virology · 2026Article
- Parents' preference for the inclusion of pediatric vaccines in the Chinese National Immunization Program: A discrete choice experiment.Human vaccines & immunotherapeutics · 2025Article
- Pentavalent rotavirus vaccine effectiveness among children in Shenzhen, China: A population-based test-negative design with directed acyclic graphs bias adjustment.Infectious medicine · 2025Article
- Article
- Molecular ingredients of an immunogen for long-lasting IgG.Frontiers in immunology · 2025Review
- Health impact of rotavirus vaccination in China.Human vaccines & immunotherapeutics · 2024Article
- Article
- Correlates of Rotavirus Vaccine Shedding and Seroconversion in a US Cohort of Healthy Infants.The Journal of infectious diseases · 2024Article
- Projected Public Health Impact of a Universal Rotavirus Vaccination Program in France.The Pediatric infectious disease journal · 2024Article
- Potential impact of rotavirus vaccination on reduction of childhood diarrheal disease in India: An analysis of National Family Health Survey-5.Vaccine: X · 2023Article
- Diversity of rotavirus strains circulating in Haiti before and after introduction of monovalent vaccine.IJID regions · 2022Article
- Rotavirus Strain Trends in United States, 2009-2016: Results from the National Rotavirus Strain Surveillance System (NRSSS).Viruses · 2022Review
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Authors and funding
27 authors.
Funding
Abstract
backgroundUsing a multicenter, active surveillance network from 2 rotavirus seasons (2012 and 2013), we assessed the vaccine effectiveness of RV5 (RotaTeq) and RV1 (Rotarix) rotavirus vaccines in preventing rotavirus gastroenteritis hospitalizations and emergency department (ED) visits for numerous demographic and secular strata.
methodsWe enrolled children hospitalized or visiting the ED with acute gastroenteritis (AGE) for the 2012 and 2013 seasons at 7 medical institutions. Stool specimens were tested for rotavirus by enzyme immunoassay and genotyped, and rotavirus vaccination histories were compared for rotavirus-positive cases and rotavirus-negative AGE controls. We calculated the vaccine effectiveness (VE) for preventing rotavirus associated hospitalizations and ED visits for each vaccine, stratified by vaccine dose, season, clinical setting, age, predominant genotype, and ethnicity.
resultsRV5-specific VE analyses included 2961 subjects, 402 rotavirus cases (14%) and 2559 rotavirus-negative AGE controls. RV1-specific VE analyses included 904 subjects, 100 rotavirus cases (11%), and 804 rotavirus-negative AGE controls. Over the 2 rotavirus seasons, the VE for a complete 3-dose vaccination with RV5 was 80% (confidence interval [CI], 74%-84%), and VE for a complete 2-dose vaccination with RV1 was 80% (CI, 68%-88%).Statistically significant VE was observed for each year of life for which sufficient data allowed analysis (7 years for RV5 and 3 years for RV1). Both vaccines provided statistically significant genotype-specific protection against predominant circulating rotavirus strains.
conclusionsIn this large, geographically and demographically diverse sample of US children, we observed that RV5 and RV1 rotavirus vaccines each provided a lasting and broadly heterologous protection against rotavirus gastroenteritis.
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