ArticleG3 (Bethesda, Md.)2015
Genome-Wide Architecture of Disease Resistance Genes in Lettuce.
Article in G3 (Bethesda, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 69 citations in OpenAlex.
- Four haplotype-resolved genome assemblies and a reference-free 66-haplotype pangenome graph for Cannabis sativa.Scientific data · 2026Article
- KCFtools: rapid alignment-free method for introgression screening and GWAS using k-mer profiles.Bioinformatics (Oxford, England) · 2026Article
- Contrasting evolutionary patterns of helper and sensor NRC NLRs in lettuce reflect functional divergence following subfunctionalization.PLoS genetics · 2026Article
- Lactuca super-pangenome reduces bias towards reference genes in lettuce research.BMC plant biology · 2024Article
- Recent advances in the improvement of genetic resistance against disease in vegetable crops.Plant physiology · 2024Review
- Conifers Concentrate Large Numbers of NLR Immune Receptor Genes on One Chromosome.Genome biology and evolution · 2024Article
- Enhanced-Efficiency Fertilizers Impact on Nitrogen Use Efficiency and Nitrous Oxide Emissions from an Open-Field Vegetable System in North China.Plants (Basel, Switzerland) · 2022Article
- Review
- Identification of genetic loci in lettuce mediating quantitative resistance to fungal pathogens.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Leaf nutrient content and transcriptomic analyses of endive (Cichorium endivia) stressed by downpour-induced waterlog reveal a gene network regulating kestose and inulin contents.Horticulture research · 2021Article
- Whole-genome resequencing of 445 Lactuca accessions reveals the domestication history of cultivated lettuce.Nature genetics · 2021Article
- Identification and mapping of new genes for resistance to downy mildew in lettuce.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Exploring sunflower responses to Sclerotinia head rot at early stages of infection using RNA-seq analysis.Scientific reports · 2020Article
- Variation Patterns of NLR Clusters inPlant communications · 2020Article
- A comprehensive analysis of the Lactuca sativa, L. transcriptome during different stages of the compatible interaction with Rhizoctonia solani.Scientific reports · 2019Article
- Recognition of lettuce downy mildew effector BLR38 in Lactuca serriola LS102 requires two unlinked loci.Molecular plant pathology · 2019Article
- Assessing the performance of different irrigation systems on lettuce (Lactuca sativa L.) in the greenhouse.PloS one · 2019Article
- Article
- Transfer of tomato immune receptor Ve1 confers Ave1-dependent Verticillium resistance in tobacco and cotton.Plant biotechnology journal · 2018Article
- The Enhancement of Plant Disease Resistance Using CRISPR/Cas9 Technology.Frontiers in plant science · 2018Review
Corrections and comments
- Erratum issuedCorrigendum.2016
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide motif searches identified 1134 genes in the lettuce reference genome of cv. Salinas that are potentially involved in pathogen recognition, of which 385 were predicted to encode nucleotide binding-leucine rich repeat receptor (NLR) proteins. Using a maximum-likelihood approach, we grouped the NLRs into 25 multigene families and 17 singletons. Forty-one percent of these NLR-encoding genes belong to three families, the largest being RGC16 with 62 genes in cv. Salinas. The majority of NLR-encoding genes are located in five major resistance clusters (MRCs) on chromosomes 1, 2, 3, 4, and 8 and cosegregate with multiple disease resistance phenotypes. Most MRCs contain primarily members of a single NLR gene family but a few are more complex. MRC2 spans 73 Mb and contains 61 NLRs of six different gene families that cosegregate with nine disease resistance phenotypes. MRC3, which is 25 Mb, contains 22 RGC21 genes and colocates with Dm13. A library of 33 transgenic RNA interference tester stocks was generated for functional analysis of NLR-encoding genes that cosegregated with disease resistance phenotypes in each of the MRCs. Members of four NLR-encoding families, RGC1, RGC2, RGC21, and RGC12 were shown to be required for 16 disease resistance phenotypes in lettuce. The general composition of MRCs is conserved across different genotypes; however, the specific repertoire of NLR-encoding genes varied particularly of the rapidly evolving Type I genes. These tester stocks are valuable resources for future analyses of additional resistance phenotypes.
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