Evidence map›Paper›PMID 26449221›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2015

The Antidiabetic and Antihypercholesterolemic Effects of an Aqueous Extract from Pecan Shells in Wistar Rats.

Luiz Carlos S Porto, Juliana da Silva, Alexandre B F Ferraz, Eduardo M Ethur, Caroline D L Porto, Norma P Marroni, Jaqueline N Picada

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Pecan (Molecules (Basel, Switzerland) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Luiz Carlos S PortoLaboratório de Genética Toxicológica, Universidade Luterana do Brasil (ULBRA), Avenida Farroupilha 8001, Canoas, CEP 92425-900, RS, Brazil.
Juliana da SilvaLaboratório de Genética Toxicológica, Universidade Luterana do Brasil (ULBRA), Avenida Farroupilha 8001, Canoas, CEP 92425-900, RS, Brazil.
Alexandre B F FerrazLaboratório de Fitoquímica, Universidade Luterana do Brasil (ULBRA), Avenida Farroupilha, 8001, Canoas, CEP 92425-900, RS, Brazil.
Eduardo M EthurCentro Universitário UNIVATES, Centro de Ciências Exatas e Tecnológicas, Rua Avelino Tallini, 171, Bairro Universitário, Lajeado, CEP 95900-000, RS, Brazil.
Caroline D L PortoUniversidade Regional Integrada (URI), Rua Univ. das Missões, 464, Santo Ângelo, CEP 98802-470, RS, Brazil.
Norma P MarroniLaboratório de Estresse Oxidativo e Antioxidantes, Universidade Luterana do Brasil (ULBRA), Avenida Farroupilha 8001, Canoas, CEP 92425-900, RS, Brazil.
Jaqueline N PicadaLaboratório de Genética Toxicológica, Universidade Luterana do Brasil (ULBRA), Avenida Farroupilha 8001, Canoas, CEP 92425-900, RS, Brazil. jnpicada@cpovo.net.
Universidade Luterana do Brasil · BRUnivates · BRUniversidade Regional Integrada do Alto Uruguai e das Missões · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pecan shell decoction has been used to treat diabetes and obesity-related diseases. In this study, the effects of a pecan shell aqueous extract (PSAE) were evaluated in diabetic and hypercholesterolemic Wistar rats, analyzing clinical signs and biochemical as well as genotoxic and mutagenic parameters, to assess its safe use and efficacy. Diabetes mellitus and hypercholesterolemia were induced with streptozotocin (STZ) and tyloxapol, respectively. Animals were orally administered PSAE (100 mg/kg body weight, b.w.) for 28 days. Biochemical analyses and genotoxicity were evaluated in blood samples and mutagenicity was evaluated in bone marrow. PSAE treatment decreased the blood glucose level and stabilized clinical signs of diabetes in diabetic rats. PSAE diminished the increase in total cholesterol and triglyceride levels in hypercholesterolemic rats. The urea levels were higher in diabetic rats than in treated ones; however, creatinine values were the same in all groups. Elevated transaminase levels were suggestive of liver injuries in diabetic rats, and were not altered by PSAE treatment. PSAE did not show genotoxic or mutagenic activities in diabetic and hypercholesterolemic rats, indicating its safe use at 100 mg/kg b.w. not only in healthy rats but also in rats with induced metabolic alterations. The findings on PSAE's efficacy may indicate that its successful and popular use is in accordance with our results. Thus, PSAE might be a potential candidate for medical purposes as a complementary treatment of diabetes and hypercholesterolemia.

Indexed as

AnimalsAnticholesteremic AgentsBlood GlucoseCaryaCholesterolDiabetes Mellitus, ExperimentalHumansHypercholesterolemiaHypoglycemic AgentsMaleNutsPhytotherapyPlant ExtractsPolyethylene GlycolsRatsRats, WistarAnticholesteremic AgentsBlood GlucoseCholesterolHypoglycemic AgentsPlant ExtractsPolyethylene GlycolsTriglyceridestyloxapolUreaWaterCarya illinoinensisComet assayMicronucleus testStreptozotocin- induced diabetes mellitusTyloxapol - induced hypercholesterolemia

Identifiers

PMID26449221
OpenAlexW1957704571

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.