ReviewJournal of orthopaedic research : official publication of the Orthopaedic Research Society2016
Multi-disciplinary antimicrobial strategies for improving orthopaedic implants to prevent prosthetic joint infections in hip and knee.
Review in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Silver-coated megaprosthesis in prevention and treatment of peri-prosthetic infections: a systematic review and meta-analysis about efficacy and toxicity in primary and revision surgery.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2021Pooled it
- A Comprehensive Literature Review for Total Hip Arthroplasty (THA): Part 2-Material Selection Criteria and Methods.Journal of functional biomaterials · 2025Review
- Optimizing vancomycin release from novel carbon fiber-reinforced polymer implants with small holes: periprosthetic joint infection treatment.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2024Article
- Biofilm Producing Methicillin-ResistantPathogens (Basel, Switzerland) · 2024Review
- Silver-integrated EDM processing of TiAl6V4 implant material has antibacterial capacity while optimizing osseointegration.Bioactive materials · 2024Article
- The Intraoperative Use of Defensive Antibacterial Coating (DACMaterials (Basel, Switzerland) · 2023Review
- Nanoscale Polishing Technique of Biomedical Grade NiTi Wire by Advanced MAF Process: Relationship between Surface Roughness and Bacterial Adhesion.Journal of functional biomaterials · 2023Article
- Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections.Antibiotics (Basel, Switzerland) · 2022Review
- Antimicrobial peptide in polymethylmethacrylate bone cement as a prophylaxis of infectious complications in orthopedics-an experiment in a murine model.Folia microbiologica · 2022Article
- Functionalized Self-Assembled Monolayers: Versatile Strategies to Combat Bacterial Biofilm Formation.Pharmaceutics · 2022Review
- Antimicrobial potential and osteoblastic cell growth on electrochemically modified titanium surfaces with nanotubes and selenium or silver incorporation.Scientific reports · 2022Article
- Surface Roughness of Titanium Orthopedic Implants Alters the Biological Phenotype of Human Mesenchymal Stromal Cells.Tissue engineering. Part A · 2021Article
- Superinfection with Difficult-to-Treat Pathogens Significantly Reduces the Outcome of Periprosthetic Joint Infections.Antibiotics (Basel, Switzerland) · 2021Article
- Use of Plasma Technologies for Antibacterial Surface Properties of Metals.Molecules (Basel, Switzerland) · 2021Review
- Synthesis and characterization of antibacterial drug loaded β-tricalcium phosphate powders for bone engineering applications.Journal of materials science. Materials in medicine · 2020Article
- Current Options and Emerging Biomaterials for Periprosthetic Joint Infection.Current rheumatology reports · 2018Review
- Initial peri- and postoperative antibiotic treatment of infected nonunions: results from 212 consecutive patients after mean follow-up of 34 months.Therapeutics and clinical risk management · 2018Article
- Advances in the local and targeted delivery of anti-infective agents for management of osteomyelitis.Expert review of anti-infective therapy · 2017Review
- Local Cellular Responses to Titanium Dioxide from Orthopedic Implants.BioResearch open access · 2017Review
- CORR Insights(®): The Role of Highly Selective Implant Retention in the Infected Hip Arthroplasty.Clinical orthopaedics and related research · 2016Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Like any foreign object, orthopaedic implants are susceptible to infection when introduced into the human body. Without additional preventative measures, the absolute number of annual prosthetic joint infections will continue to rise, and may exceed the capacity of health care systems in the near future. Bacteria are difficult to eradicate from synovial joints due to their exceptionally diverse taxonomy, complex mechanistic attachment capabilities, and tendency to evolve antibiotic resistance. When a primary orthopaedic implant fails from prosthetic joint infection, surgeons are generally challenged by limited options for intervention. In this review, we highlight the etiology and taxonomic groupings of bacteria known to cause prosthetic joint infections, and examine their key mechanisms of attachment. We propose that antimicrobial strategies should focus on the most harmful bacteria taxa within the context of occurrence, taxonomic diversity, adhesion mechanisms, and implant design. Patient-specific identification of organisms that cause prosthetic joint infections will permit assessment of their biological vulnerabilities. The latter can be targeted using a range of antimicrobial techniques that exploit different colonization mechanisms including implant surface attachment, biofilm formation, and/or hematogenous recruitment. We anticipate that customized strategies for each patient, joint, and prosthetic component will be most effective at reducing prosthetic joint infections, including those caused by antibiotic-resistant and polymicrobial bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.