Evidence map›Paper›PMID 26449188›Full record

ArticleOncotarget2015

Serotonin 6 receptor controls Alzheimer's disease and depression.

Hyung-Mun Yun, Kyung-Ran Park, Eun-Cheol Kim, Sanghyeon Kim, Jin Tae Hong

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 60 citations in OpenAlex.

  1. Glial Cells in Behavioral and Psychological Symptoms of Alzheimer's Disease.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Hyung-Mun YunDepartment of Maxillofacial Tissue Regeneration, School of Dentistry and Research Center for Tooth and Periodontal Regeneration (MRC), Kyung Hee University, Seoul, Republic of Korea.
Kyung-Ran ParkDepartment of Oral & Maxillofacial Regeneration, Kyung Hee University, Seoul, Republic of Korea.
Eun-Cheol KimDepartment of Maxillofacial Tissue Regeneration, School of Dentistry and Research Center for Tooth and Periodontal Regeneration (MRC), Kyung Hee University, Seoul, Republic of Korea.
Sanghyeon KimStanley Brain Research Laboratory, Stanley Medical Research Institute, Rockville, MD, USA.
Jin Tae HongCollege of Pharmacy and Medical Research Center, Chungbuk National University, Chungbuk, Republic of Korea.
Kyung Hee University · KRChungbuk National University · KRStanley Medical Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) and depression in late life are one of the most severe health problems in the world disorders. Serotonin 6 receptor (5-HT6R) has caused much interest for potential roles in AD and depression. However, a causative role of perturbed 5-HT6R function between two diseases was poorly defined. In the present study, we found that a 5-HT6R antagonist, SB271036 rescued memory impairment by attenuating the generation of Aβ via the inhibition of γ-secretase activity and the inactivation of astrocytes and microglia in the AD mouse model. It was found that the reduction of serotonin level was significantly recovered by SB271036, which was mediated by an indirect regulation of serotonergic neurons via GABA. Selective serotonin reuptake inhibitor (SSRI), fluoxetine significantly improved cognitive impairment and behavioral changes. In human brain of depression patients, we then identified the potential genes, amyloid beta (A4) precursor protein-binding, family A, member 2 (APBA2), well known AD modulators by integrating datasets from neuropathology, microarray, and RNA seq. studies with correlation analysis tools. And also, it was demonstrated in mouse models and patients of AD. These data indicate functional network of 5-HT6R between AD and depression.

Indexed as

Gene Expression RegulationAdaptor Proteins, Signal TransducingAlzheimer DiseaseAmyloidAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAnimalsAstrocytesBehavior, AnimalBrainCadherinsCarrier ProteinsCognition DisordersDepressionDisease Models, AnimalFluoxetineAdaptor Proteins, Signal TransducingAmyloidAmyloid beta-Peptidesamyloid beta-protein (1-42)Amyloid Precursor Protein SecretasesAPBA1 protein, humanApba1 protein, mouseAPBA2 protein, humanApba2 protein, mouseCadherinsCarrier ProteinsFluoxetineNerve Tissue ProteinsPeptide FragmentsReceptors, Serotoninserotonin 6 receptorSerotonin and Noradrenaline Reuptake InhibitorsSerotonin Antagonists5-HT6RAlzheimer’s diseaseAPBA1/2depressionserotonin

Identifiers

PMID26449188
PMCPMC4694947
OpenAlexW1933444002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.