ReviewJournal of blood transfusion2015
CRASH-2 Study of Tranexamic Acid to Treat Bleeding in Trauma Patients: A Controversy Fueled by Science and Social Media.
Review in Journal of blood transfusion, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Safety and efficacy of tranexamic acid in minimizing perioperative bleeding in extrahepatic abdominal surgery: meta-analysis.BJS open · 2021Pooled it
- Geographical Variance in the Use of Tranexamic Acid for Major Trauma Patients.Medicina (Kaunas, Lithuania) · 2019Pooled it
- Medullary cavity application of tranexamic acid to reduce blood loss in tibial intramedullary nailing procedures-a randomized controlled trial.International orthopaedics · 2023Trial
- Local delivery of tranexamic acid for hemorrhage control in trauma: a narrative review.Frontiers in drug delivery · 2026Review
- Use of Tranexamic Acid in SARS-COV-2: Boon or Bane?Archives of Razi Institute · 2024Review
- Perioperative Considerations in Management of the Severely Bleeding Coagulopathic Patient.Anesthesiology · 2023Article
- The Pathophysiology and Management of Hemorrhagic Shock in the Polytrauma Patient.Journal of clinical medicine · 2021Review
- Effectiveness and Adverse Effects of Tranexamic Acid in Bleeding during Adenotonsillectomy: A Randomized, Controlled, Double-blind Clinical Trial.International archives of otorhinolaryngology · 2021Article
- Viscoelastic Hemostatic Assays for Postpartum Hemorrhage.Journal of clinical medicine · 2021Review
- [Tranexamic acid for bleeding prophylaxis in orthopedic surgery and trauma-standard or customized therapy?]Der Anaesthesist · 2021Review
- Early prediction of acute traumatic coagulopathy: a validation of the COAST score using the German Trauma Registry.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021Article
- Article
- Efficacy of Tranexamic Acid in Reducing Blood Loss in Lower Segment Cesearean Section: A Randomised Controlled Study.Journal of obstetrics and gynaecology of India · 2020Article
- The many roles of tranexamic acid: An overview of the clinical indications for TXA in medical and surgical patients.European journal of haematology · 2020Review
- Tranexamic acid is associated with selective increase in inflammatory markers following total knee arthroplasty (TKA): a pilot study.Journal of orthopaedic surgery and research · 2018Article
- Antifibrinolytic Therapy and Perioperative Considerations.Anesthesiology · 2018Review
- Tissue injury suppresses fibrinolysis after hemorrhagic shock in nonhuman primates (rhesus macaque).The journal of trauma and acute care surgery · 2017Article
- Administration of tranexamic acid in trauma patients under stricter inclusion criteria increases the treatment window for stabilization from 24 to 48 hours-a retrospective review.International journal of burns and trauma · 2017Article
- Tranexamic Acid (TXA) in Trauma Patients: Barriers to Use among Trauma Surgeons and Emergency Physicians.Emergency medicine international · 2017Article
- Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient.Transfusion · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper reviews the application of tranexamic acid, an antifibrinolytic, to trauma. CRASH-2, a large randomized controlled trial, was the first to show a reduction in mortality and recommend tranexamic acid use in bleeding trauma patients. However, this paper was not without controversy. Its patient recruitment, methodology, and conductance in moderate-to-low income countries cast doubt on its ability to be applied to trauma protocols in countries with mature trauma networks. In addition to traditional vetting in scientific, peer-reviewed journals, CRASH-2 came about at a time when advances in communication technology allowed debate and influence to be leveraged in new forms, specifically through the use of multimedia campaigns, social media, and Internet blogs. This paper presents a comprehensive view of tranexamic acid utilization in trauma from peer-reviewed evidence to novel multimedia influences.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.