ArticleBMC obesity2015
Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults.
Article in BMC obesity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01049698 (Improving Muscle for Functional Independence Trial), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Muscle for Functional Independence Trial
Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Muscle mitochondria, function, mass, and quality of life in prostate cancer during androgen deprivation therapy.Nature communications · 2026Article
- Comparative analysis of bariatric surgery outcomes and preoperative body composition in individuals with obesity with and without binge-eating disorder: a retrospective study.Journal of eating disorders · 2026Article
- Platelet Mitochondrial Function, Physical Performance, and Body Composition in Older People Living with HIV: A Preliminary Study.International journal of molecular sciences · 2026Article
- Incretin Receptor Agonism, Fat-free Mass, and Cardiorespiratory Fitness: A Narrative Review.The Journal of clinical endocrinology and metabolism · 2025Review
- Skeletal Muscle Composition, Power, and Mitochondrial Energetics in Older Men and Women With Knee Osteoarthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2024Article
- Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women.Obesity (Silver Spring, Md.) · 2024Article
- Increased adiposity is associated with altered skeletal muscle energetics.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Sex differences in the relationships between body composition, fat distribution, and mitochondrial energy metabolism: a pilot study.Nutrition & metabolism · 2022Article
- Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function.Nature communications · 2021Article
- Silver Nanoparticles Induce Mitochondrial Protein Oxidation in Lung Cells Impacting Cell Cycle and Proliferation.Antioxidants (Basel, Switzerland) · 2019Article
- Triphenylphosphonium-Derived Protein Sulfenic Acid Trapping Agents: Synthesis, Reactivity, and Effect on Mitochondrial Function.Chemical research in toxicology · 2019Article
- Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin.Molecular metabolism · 2019Article
- Regional Adipose Distribution and its Relationship to Exercise Intolerance in Older Obese Patients Who Have Heart Failure With Preserved Ejection Fraction.JACC. Heart failure · 2018Article
- Mitochondria-targeted Probes for Imaging Protein Sulfenylation.Scientific reports · 2018Article
- Article
- Brain Oxidative Stress During Experimental Sepsis Is Attenuated by Simvastatin Administration.Molecular neurobiology · 2017Article
- Monocyte bioenergetic function is associated with body composition in virologically suppressed HIV-infected women.Redox biology · 2017Article
- The impact of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men.Journal of cachexia, sarcopenia and muscle · 2017Article
- Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery.BMC medicine · 2017Article
- Long-chain acyl-CoA synthetase 6 regulates lipid synthesis and mitochondrial oxidative capacity in human and rat skeletal muscle.The Journal of physiology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMitochondrial function declines with age; however, the relationship between adiposity and mitochondrial function among older adults is unclear. This study examined relationships between skeletal muscle mitochondrial content and electron transport chain complex 2 driven respiration with whole body and thigh composition, body fat distribution, and insulin sensitivity in older adults.
methods25 healthy, sedentary, weight-stable men (N = 13) and women (N = 12) >65 years of age, with a BMI range of 18-35 kg/m(2), participated in this study. Vastus lateralis biopsies were analyzed for citrate synthase (CS) activity and succinate mediated respiration of isolated mitochondria. Whole body and thigh composition were measured by DXA and CT. HOMA-IR was calculated using fasting glucose and insulin as an estimate of insulin sensitivity.
resultsSimilar to reports in middle-aged adults, skeletal muscle CS activity was negatively correlated with BMI (R = -0.43) in our cohort of older adults. Higher total and thigh adiposity were correlated with lower CS activity independent of BMI (R = -0.50 and -0.71 respectively). Maximal complex 2 driven mitochondrial respiration was negatively correlated with lower body adiposity in males (R = -0.66). In this cohort of non-diabetic older adults, both HOMA-IR and insulin were positively correlated with CS activity when controlling for BMI (R = 0.57 and 0.66 respectively).
conclusionsAdiposity and body composition are correlated with skeletal muscle mitochondrial content and electron transport chain function in healthy, sedentary, community dwelling, older adults. Specific relationships of mitochondrial bioenergetics with gender and insulin sensitivity are also apparent.
trial registrationClinicalTrials.gov identifier NCT01049698.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.