Evidence map›Paper›PMID 26448855›Full record

ArticleAsian journal of sports medicine2015

Protective Role of Aerobic Exercise Against Cisplatin-Induced Nephrotoxicity in Rats.

Farzaneh Zeynali, Mehdi Nematbakhsh, Hossain Mojtahedi, Aliasghar Poorshahnazari, Ardeshir Talebi, Zahra Pezeshki, Safoora Mazaheri, Fatemeh Moslemi

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In one paragraph

Article in Asian journal of sports medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Farzaneh ZeynaliWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran ; Department of Physical Education, Faculty of Physical Education, Isfahan University, Isfahan, IR Iran.
Mehdi NematbakhshWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran ; Department of Physiology, Isfahan University of Medical Sciences, Isfahan, IR Iran ; Isfahan -MN Institute of Basic and Applied Sciences Research, Isfahan, IR Iran.
Hossain MojtahediDepartment of Physical Education, Faculty of Physical Education, Isfahan University, Isfahan, IR Iran.
Aliasghar PoorshahnazariDepartment of Physiology, Isfahan University of Medical Sciences, Isfahan, IR Iran.
Ardeshir TalebiWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran ; Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, IR Iran.
Zahra PezeshkiWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran.
Safoora MazaheriWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran.
Fatemeh MoslemiWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran.
Isfahan University of Medical Sciences · IRUniversity of Isfahan · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCisplatin (CP) is a chemotherapy drug and nephrotoxicity is considered as its major side effect. Aerobic exercise is well known as an approach to reduce the side effects of many drugs.

objectivesThis study was designed to determine the protective role of aerobic exercise against CP-induced nephrotoxicity. MATERIALS AND

methodsThirty male Wistar rats were randomly divided into four groups. Group I had aerobic exercise on a treadmill one hour per day and five days per week for eight weeks. Then, the exercise protocol was continued for another week, but during this week, the animals also received CP (2.5 mg/kg/day; ip). Group II underwent the same protocol as group I without exercise in the last week during the CP therapy. Groups III and IV were assigned as positive and negative control groups, and were treated with CP and saline without exercise, respectively. Finally, the animals were sacrificed for the biochemical measurement and tissue histopathology investigation.

resultsCP alone without exercise increased serum levels of blood urea nitrogen (BUN), creatinine (Cr), and malondialdehyde (MDA); and kidney nitrite level, while treadmill exercise in group I significantly ameliorated these parameters (P < 0.05). Kidney and serum levels of MDA and nitrite did not alter significantly. Also, the severity of kidney tissue damage decreased significantly in groups I and II (P < 0.05).

conclusionsAerobic exercise may reduce CP-induced nephrotoxicity with a favorable effect on renal function by increasing activation of antioxidant system.

Indexed as

CisplatinExerciseNephrotoxicityRats

Identifiers

PMID26448855
PMCPMC4594143
OpenAlexW1810354665

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.