ArticlePLoS genetics2015
A Novel Route Controlling Begomovirus Resistance by the Messenger RNA Surveillance Factor Pelota.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 161 citations in OpenAlex.
- A dominant mutation in tomato DNA POLYMERASE DELTA 1 causes geminivirus DNA replication catastrophe.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Advances in genomics-driven genetic decoding and genomic design breeding in tomato.Horticulture research · 2026Article
- Leaf Curl Disease Resistance Landscaping in Homozygous Ty-Gene Donor Tomato Genotypes Using a Robust Disease Scoring System and Indexing of Begomoviruses Under Natural Epiphytotic Conditions.Current microbiology · 2026Article
- The prospects of targeting messenger RNA surveillance factor PELOTA for developing virus resistance in plants.Plant molecular biology · 2026Review
- Elucidation of theFrontiers in plant science · 2026Article
- Ey-1 encodes a DEDDh exonuclease in eggplant (Solanum melongena), providing a novel pathway for begomovirus resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- A TIR-NLR gene from Arabidopsis Pla-1 confers resistance to geminivirus infection.The Plant journal : for cell and molecular biology · 2025Article
- Article
- Roles of No-Go RNA decay in the control of plant viruses and transposable elements.BMC plant biology · 2025Review
- Allelic value in gene regulation-implications for gene editing.Annals of botany · 2025Article
- ExploringTy resistance genes and genetic diversity in improved tomato lines selected from commercial hybrids.BMC plant biology · 2025Article
- Pelota: A double-edged sword in virus infection.PLoS pathogens · 2025Review
- Molecular breeding of tomato: Advances and challenges.Journal of integrative plant biology · 2025Review
- Article
- The tomato gene Ty-6, encoding DNA polymerase delta subunit 1, confers broad resistance to Geminiviruses.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Engineering tomato disease resistance by manipulating susceptibility genes.Frontiers in genome editing · 2025Review
- Breeding vegetables for whitefly resistance: past, present, and future in the AI era.Frontiers in plant science · 2025Review
- Marker assisted pyramiding of major resistance genes of tomato leaf curl and late blight diseases for stabilising tomato production.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Advances in understanding the interaction betweenPlant signaling & behavior · 2024Review
- Resistance gene Ty-1 restricts TYLCV infection in tomato by increasing RNA silencing.Virology journal · 2024Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tomato yellow leaf curl virus (TYLCV) is a devastating disease of tomato (Solanum lycopersicum) that can be effectively controlled by the deployment of resistant cultivars. The TYLCV-resistant line TY172 carries a major recessive locus for TYLCV resistance, designated ty-5, on chromosome 4. In this study, the association between 27 polymorphic DNA markers, spanning the ty-5 locus, and the resistance characteristics of individual plants inoculated with TYLCV in 51 segregating recombinant populations were analyzed. These analyses localized ty-5 into a 425 bp region containing two transversions: one in the first exon of a gene encoding the tomato homolog of the messenger RNA surveillance factor Pelota (Pelo), and a second in its proximal promoter. Analyses of susceptible and resistant lines revealed that the relative transcript level of the gene remained unchanged, regardless of whether the plants were infected with TYLCV or not. This suggests that the polymorphism discovered in the coding region of the gene controls the resistance. Silencing of Pelo in a susceptible line rendered the transgenic plants highly resistant, while in the resistant line TY172 had no effect on symptom development. In addition, over-expression of the susceptible allele of the gene in the resistant TY172 line rendered it susceptible, while over-expression of the resistant allele in susceptible plants had no effect. These results confirm that Pelo is the gene controlling resistance at the ty-5 locus. Pelo, implicated in the ribosome recycling-phase of protein synthesis, offers an alternative route to promote resistance to TYLCV and other viruses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.