Observational studyMedicine2015
Connectome Reorganization Associated With Surgical Outcome in Temporal Lobe Epilepsy.
Observational study in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Thalamic organization differentially contributes to clinical conditions in epilepsy.Communications medicine · 2026Article
- Longitudinal quantitative streamline tractography: robust estimation of white matter connectivity differences.bioRxiv : the preprint server for biology · 2026Article
- The impact of resective epilepsy surgery on the brain network: evidence from post-surgical imaging.Brain : a journal of neurology · 2025Review
- Independent component analysis of resting-state fMRI identifies regions associated with seizure freedom after laser interstitial thermal therapy for temporal lobe epilepsy.Frontiers in neurology · 2025Article
- Connectome reorganization associated with temporal lobe pathology and its surgical resection.Brain : a journal of neurology · 2024Article
- Progressive remodeling of structural networks following surgery for operculo-insular epilepsy.Frontiers in neurology · 2024Article
- Structural networking of the developing brain: from maturation to neurosurgical implications.Frontiers in neuroanatomy · 2023Review
- Volumetric and structural connectivity abnormalities co-localise in TLE.NeuroImage. Clinical · 2022Article
- Article
- Structural Connectivity Alterations in Operculo-Insular Epilepsy.Brain sciences · 2021Article
- Structural Brain Network Abnormalities and the Probability of Seizure Recurrence After Epilepsy Surgery.Neurology · 2021Article
- Distributed Functional Connectome of White Matter in Patients With Functional Dyspepsia.Frontiers in human neuroscience · 2021Article
- Individual Brain Metabolic Connectome Indicator Based on Jensen-Shannon Divergence Similarity Estimation Predicts Seizure Outcomes of Temporal Lobe Epilepsy.Frontiers in cell and developmental biology · 2021Article
- Executive function and its relation to anatomical connectome in homosexual and heterosexual men.Quantitative imaging in medicine and surgery · 2020Article
- Post-traumatic Stress Disorder With Flashbacks of an Old Childhood Memory Triggered by Right Temporal Lobe Epilepsy Surgery in Adulthood.Frontiers in psychiatry · 2020Article
- Regional and network properties of white matter function in Parkinson's disease.Human brain mapping · 2019Article
- Role of mesial temporal lobe structures in sensory processing in humans: a prepulse modulation study in temporal lobe epilepsy.Experimental brain research · 2018Article
- White matter network topology relates to cognitive flexibility and cumulative neurological risk in adult survivors of pediatric brain tumors.NeuroImage. Clinical · 2018Article
- Cognition and connectomes in nondementia idiopathic Parkinson's disease.Network neuroscience (Cambridge, Mass.) · 2018Article
- The impact of epilepsy surgery on the structural connectome and its relation to outcome.NeuroImage. Clinical · 2018Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify the distinct pattern of anatomical network reorganization in surgically refractory mesial temporal lobe epilepsy (MTLE) patients using a longitudinal design. We collected longitudinal diffusion-weighted images of 19 MTLE patients before and after anterior temporal lobectomy. Patients were classified as seizure-free (SF) or nonseizure-free (NSF) at least 1 year after surgery. We constructed whole-brain anatomical networks derived from white matter tractography and evaluated network connectivity measures by graph theoretical analysis. The reorganization trajectories of network measures in SF and NSF patients were investigated by two-way mixed analysis of variance, with factors "group" (SF vs NSF) and "treatment" (presurgery vs postsurgery). Widespread brain structures showed opposite reorganization trajectories in FS and NSF groups (interaction effect). Most of them showed group difference before surgery and then converge after surgery, suggesting that surgery remodeled these structures into a similar status. Conversly, contralateral amygdala-planum-temporale and thalamic-parietal tracts showed higher connectivity strength in NSF than in SF patients after surgery, indicating maladaptive neuroplastic responses to surgery in NSF patients. Our findings suggest that surgical outcomes are associated not only with the preoperative pattern of anatomical connectivity, but also with connectome reconfiguration following surgery. The reorganization of contralateral temporal lobe and corticothalamic tracts may be particularly important for seizure control in MTLE.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.