ArticleMedicine2015
Multiple Rapid Swallow Maneuver Enhances the Clinical Utility of High-Resolution Manometry in Patients Showing Ineffective Esophageal Motility.
Article in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Clinical profile and manometry characteristics of patients with motor dysphagia.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Creation and validation of manometry GERD score to predict positive reflux test (gastroesophageal reflux disease).Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Article
- Interpretation of Impedance Data on High-resolution Impedance Manometry Studies-A Worldwide Survey.Journal of neurogastroenterology and motility · 2024Article
- Effect of inter-swallow interval on striated esophagus peristalsis; a comparative study with smooth muscle esophagus.Neurogastroenterology and motility · 2023Article
- Observational
- Concise Review: Applicability of High-resolution Manometry in Gastroesophageal Reflux Disease.Journal of neurogastroenterology and motility · 2022Review
- The Supportive Role of Provocative Maneuvers and Impedance Clearance in Detecting Ineffective Esophageal Motility.Gastroenterology research · 2022Article
- Advancing high-resolution manometry: evaluating the use of multiple rapid swallows versus apple viscous swallows in clinical practice.Esophagus : official journal of the Japan Esophageal Society · 2022Article
- A Comparative Assessment of the Diagnosis of Swallowing Impairment and Gastroesophageal Reflux in Canines and Humans.Frontiers in veterinary science · 2022Review
- More beads, more peristaltic reserve, better outcomes: factors predicting postoperative dysphagia after magnetic sphincter augmentation.Surgical endoscopy · 2021Article
- Evaluation of esophageal motor function in patients with gastroesophageal reflux using multiple rapid swallows.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Article
- [Diagnosis of Dysphagia: High Resolution Manometry & EndoFLIP].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2021Review
- Management of Ineffective Esophageal Hypomotility.Frontiers in pharmacology · 2021Review
- Role of the Rapid Drink Challenge Test in Esophageal Motility Disorder Diagnosis.Journal of neurogastroenterology and motility · 2020Article
- Esophageal Motor Dysfunctions in Gastroesophageal Reflux Disease and Therapeutic Perspectives.Journal of neurogastroenterology and motility · 2019Review
- Ineffective esophageal motility: Concepts, future directions, and conclusions from the Stanford 2018 symposium.Neurogastroenterology and motility · 2019Review
- High-Resolution Manometry Diagnosis of Ineffective Esophageal Motility Is Associated with Higher Reflux Burden.Digestive diseases and sciences · 2019Article
- Multiple rapid swallow testing in patients with gastroesophageal reflux disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2018Article
- Ineffective esophageal motility and the vagus: current challenges and future prospects.Clinical and experimental gastroenterology · 2016Review
- High prevalence of esophagitis in patients with severe ineffective esophageal motility: need for a new diagnostic cutoff.Annals of gastroenterologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical significance of ineffective esophageal motility (IEM) together with multiple rapid swallow (MRS) has not been yet evaluated in the Chicago Classification v3.0. This study evaluated the adjunctive role of MRS in IEM and determined the criteria of abnormal MRS to maximize the utility of IEM. We analyzed 186 patients showing IEM or normal esophageal motility (NEM), who underwent esophageal high-resolution impedance-manometry for esophageal symptoms. Two different criteria for abnormal MRS were applied to IEM subjects, resulting in 2 corresponding subgroups: IEM-A when distal contractile integral (DCI) ratio between an average wet swallows and MRS contraction was < 1 and IEM-B when MRS contraction DCI was <450 mm Hg-s-cm. One IEM subject inadequately performed MRS. Among the remaining 52 IEM subjects, 18 (34.6%) were classified into IEM-A and 23 (44.2%) into IEM-B. IEM subjects showed less complete bolus transit (median 0.0%, interquartile range 0.0-20.0% vs 60.0%, 30.0-80.0; P < 0.001) resulting in higher impaired bolus transit than NEM subjects (98.1% vs 66.9%, P = 0.001). IEM-B subjects showed additionally higher pathologic bolus exposure than NEM subjects (55.6% vs 29.3%, P = 0.001), whereas IEM-A subjects could not. Although IEM-B subjects had the highest prevalence of gastroesophageal reflux disease among the subjects groups, it did not reach statistical significance. In conclusion, IEM patients with abnormal MRS contraction have an increased risk of prolonged bolus clearance, poor bolus transit, and pathologic bolus exposure. IEM patients need to be assessed concerning whether MRS contraction DCI is < 450 mm Hg-s-cm to segregate clinically relevant patients.
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