ArticleJournal of biomedical optics2015
Swept-source optical coherence tomography powered by a 1.3-μm vertical cavity surface emitting laser enables 2.3-mm-deep brain imaging in mice in vivo.
Article in Journal of biomedical optics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Intravital 3D visualization and segmentation of murine neural networks at micron resolution.Scientific reports · 2022Article
- OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives.Diagnostics (Basel, Switzerland) · 2022Review
- Extended focal depth Fourier domain optical coherence microscopy with a Bessel-beam - LPBiomedical optics express · 2021Article
- Through the looking glass: A review of cranial window technology for optical access to the brain.Journal of neuroscience methods · 2021Review
- Soliton microcomb based spectral domain optical coherence tomography.Nature communications · 2021Article
- Imaging Motion: A Comprehensive Review of Optical Coherence Tomography Angiography.Advances in experimental medicine and biology · 2021Review
- Capability of physically reasonable OCT-based differentiation between intact brain tissues, human brain gliomas of different WHO grades, and glioma model 101.8 from rats.Biomedical optics express · 2020Article
- Signal-to-background ratio and lateral resolution in deep tissue imaging by optical coherence microscopy in the 1700 nm spectral band.Scientific reports · 2019Article
- Computed optical coherence microscopy of mouse brain ex vivo.Journal of biomedical optics · 2019Article
- Optical coherence tomography angiography in preclinical neuroimaging.Biomedical engineering letters · 2019Review
- Speckle modulation enables high-resolution wide-field human brain tumor margin detection and in vivo murine neuroimaging.Scientific reports · 2019Article
- High-spatial-resolution deep tissue imaging with spectral-domain optical coherence microscopy in the 1700-nm spectral band.Journal of biomedical optics · 2019Article
- Laser brain cancer surgery in a xenograft model guided by optical coherence tomography.Theranostics · 2019Article
- New Endoscopic Imaging Technology Based on MEMS Sensors and Actuators.Micromachines · 2017Article
- Visualization of neuritic plaques in Alzheimer's disease by polarization-sensitive optical coherence microscopy.Scientific reports · 2017Article
- Extended-focus optical coherence microscopy for high-resolution imaging of the murine brain.Biomedical optics express · 2016Article
- Optical coherence microscopy in 1700 nm spectral band for high-resolution label-free deep-tissue imaging.Scientific reports · 2016Article
- Acute insertion effects of penetrating cortical microelectrodes imaged with quantitative optical coherence angiography.Neurophotonics · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We report noninvasive, in vivo optical imaging deep within a mouse brain by swept-source optical coherence tomography (SS-OCT), enabled by a 1.3-μm vertical cavity surface emitting laser (VCSEL). VCSEL SS-OCT offers a constant signal sensitivity of 105 dB throughout an entire depth of 4.25 mm in air, ensuring an extended usable imaging depth range of more than 2 mm in turbid biological tissue. Using this approach, we show deep brain imaging in mice with an open-skull cranial window preparation, revealing intact mouse brain anatomy from the superficial cerebral cortex to the deep hippocampus. VCSEL SS-OCT would be applicable to small animal studies for the investigation of deep tissue compartments in living brains where diseases such as dementia and tumor can take their toll.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.