ReviewSleep medicine reviews2016
Obstructive sleep apnea and cancer: Epidemiologic links and theoretical biological constructs.
Review in Sleep medicine reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 123 citations in OpenAlex.
- Impact of Sleep Health Domains on Chronic Conditions: Findings from a Cross-Sectional Analysis Using Data from the NHANES 2017-2020.Sleep science (Sao Paulo, Brazil) · 2026Article
- Is obstructive sleep apnea a driver of cancer and chronic disease risk? A real-world analysis of over 3 million patients.BMC pulmonary medicine · 2026Article
- The influence of habitual consumption of alcohol on the incidence of obstructive sleep apnea: a national population-based cohort study.Sleep & breathing = Schlaf & Atmung · 2026Article
- Rising Mortality from Sleep Apnea and Hypertension in U.S. Adults: A 23-Year Epidemiological Analysis And Impact of the COVID-19 Pandemic (2000-2023).Journal of epidemiology and global health · 2026Article
- Exploring the genetic overlap between obstructive sleep apnea and prostate cancer.Journal of the National Cancer Center · 2026Article
- Obstructive sleep apnea in never-smokers with newly diagnosed lung cancer: a prospective study in a predominantly female Korean population.Scientific reports · 2026Observational
- [Research Advances in Obstructive Sleep Apnea and Lung Cancer Comorbidity].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2026Review
- The vicious cycle of circadian disruption and obstructive sleep apnea: implications for cancer risk.Journal of the National Cancer Center · 2026Article
- Association of nasopharynx cancer with obstructive sleep apnea.Frontiers in oncology · 2026Article
- Cancer and obstructive sleep apnea.Chinese medical journal · 2025Article
- Sleep health: an unappreciated key player in colorectal cancer.Journal of Cancer · 2025Review
- Interleukins as a potential link between obstructive sleep apnea and renal cell carcinoma.Contemporary oncology (Poznan, Poland) · 2025Review
- Article
- Advances in immunology of obstructive sleep apnea: mechanistic insights, clinical impact, and therapeutic perspectives.Frontiers in immunology · 2025Review
- Association of obstructive sleep apnea with risk of lung cancer: a nationwide cohort study in Korea.Scientific reports · 2024Article
- A cross-sectional analysis of the association between sleep disorders and cancer using data from the National Health and Nutrition Examination Survey (NHANES) 2005-2014.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Identification of key genes in chronic intermittent hypoxia-induced lung cancer progression based on transcriptome sequencing.BMC cancer · 2024Article
- Linking obstructive sleep apnoea and lung cancer: a further step down the road.ERJ open research · 2024Article
- Association between obstructive sleep apnea and risk of lung cancer: findings from a collection of cohort studies and Mendelian randomization analysis.Frontiers in oncology · 2024Article
- Sex-specific associations between habitual snoring and cancer prevalence: insights from a US Cohort Study.Sleep advances : a journal of the Sleep Research Society · 2024Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Sleep disorders have emerged as highly prevalent conditions in the last 50-75 y. Along with improved understanding of such disorders, the realization that perturbations in sleep architecture and continuity may initiate, exacerbate or modulate the phenotypic expression of multiple diseases including cancer has gained increased attention. Furthermore, the intermittent hypoxia that is attendant to sleep disordered breathing, has recently been implicated in increased incidence and more adverse prognosis of cancer. The unifying conceptual framework linking these associations proposes that increased sympathetic activity and/or alterations in immune function, particularly affecting innate immune cellular populations, underlie the deleterious effects of sleep disorders on tumor biology. In this review, the epidemiological evidence linking disrupted sleep and intermittent hypoxia to oncological outcomes, and the potential biological underpinnings of such associations as illustrated by experimental murine models will be critically appraised. The overarching conclusion appears supportive in the formulation of an hypothetical framework, in which fragmented sleep and intermittent hypoxia may promote changes in multiple signalosomes and transcription factors that can not only initiate malignant transformation, but will also alter the tumor microenvironment, disrupt immunosurveillance, and thus hasten tumor proliferation and increase local and metastatic invasion. Future bench-based experimental studies as well as carefully conducted and controlled clinical epidemiological studies appear justified for further exploration of these hypotheses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.