ArticlePloS one2015
In-Depth Characterization of Sheep (Ovis aries) Milk Whey Proteome and Comparison with Cow (Bos taurus).
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 64 citations in OpenAlex.
- An Overview of Advancements in Proteomic Approaches to Enhance Livestock Production and Aquaculture.Animals : an open access journal from MDPI · 2025Review
- Bacterial microbiota diversity in sheep milk during refrigerated storage under different processing conditions.Scientific reports · 2025Article
- Probiotic Whey-Based Beverages from Cow, Sheep and Goat Milk: Antioxidant Activity, Culture Viability, Amino Acid Contents.Foods (Basel, Switzerland) · 2023Article
- Article
- Non-Bovine Milk: Sources and Future Prospects.Foods (Basel, Switzerland) · 2022Article
- Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures.Reproduction (Cambridge, England) · 2022Article
- Comparative Structural and Compositional Analyses of Cow, Buffalo, Goat and Sheep Cream.Foods (Basel, Switzerland) · 2021Article
- Amino Acid Sequences of Lactoferrin from Red Deer (Foods (Basel, Switzerland) · 2021Article
- Transcriptome Atlas of 16 Donkey Tissues.Frontiers in genetics · 2021Article
- The Differential Composition of Whey Proteomes in Hu Sheep Colostrum and Milk during Different Lactation Periods.Animals : an open access journal from MDPI · 2020Article
- Circulating Branched Chain Amino Acid Concentrations Are Higher in Dairy-Avoiding Females Following an Equal Volume of Sheep Milk Relative to Cow Milk: A Randomized Controlled Trial.Frontiers in nutrition · 2020Article
- Article
- Exploration of ovine milk whey proteome during postnatal development using an iTRAQ approach.PeerJ · 2020Article
- Use of Proteomics in the Study of Mastitis in Ewes.Pathogens (Basel, Switzerland) · 2019Review
- Proteomic Analyses of Mammary Glands Provide Insight into the Immunity and Metabolism Pathways Associated with Clinical Mastitis in Meat Sheep.Animals : an open access journal from MDPI · 2019Article
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An in-depth proteomic study of sheep milk whey is reported and compared to the data available in the literature for the cow whey proteome. A combinatorial peptide ligand library kit (ProteoMiner) was used to normalize protein abundance in the sheep whey proteome followed by an in-gel digest of a 1D-PAGE display and an in-solution digestion followed by OFFGEL isoelectric focusing fractionation. The peptide fractions obtained were then analyzed by LC-MS/MS. This enabled identification of 669 proteins in sheep whey that, to our knowledge, is the largest inventory of sheep whey proteins identified to date. A comprehensive list of cow whey proteins currently available in the literature (783 proteins from unique genes) was assembled and compared to the sheep whey proteome data obtained in this study (606 proteins from unique genes). This comparison revealed that while the 233 proteins shared by the two species were significantly enriched for immune and inflammatory responses in gene ontology analysis, proteins only found in sheep whey in this study were identified that take part in both cellular development and immune responses, whereas proteins only found in cow whey in this study were identified to be associated with metabolism and cellular growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.